Euromed Research Center, Engineering Division, Euro-Med University of Fes (UEMF), Route de Meknes, Rond-point de Bensouda, 30070, Fès, Morocco; Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials, Faculty of Sciences and Technologies, Cadi Ayyad University, Avenue Abdelkrim Elkhattabi, B.P. 549, 40000, Marrakech, Morocco.
Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials, Faculty of Sciences and Technologies, Cadi Ayyad University, Avenue Abdelkrim Elkhattabi, B.P. 549, 40000, Marrakech, Morocco.
Carbohydr Polym. 2018 Mar 1;183:287-293. doi: 10.1016/j.carbpol.2017.12.036. Epub 2017 Dec 16.
Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforward concepts enabling to circumvent this bottleneck are missing in the open literature. In this framework, we report herein on aldehyde-functionalized, transparent and flexible chitosan-montmorillonite hybrid films that act as a new generation of eco-friendly, controlled-chemical release bioplastics. These dynamically-assembled nanomaterials are designed by a ternary assembly from biowaste derived chitin biopolymer, aromatic aldehydes and layered clay nanoparticles. On the basis of their geometrical and conformational properties, the oxygenated groups on the grafted aromatics interact preferentially with either the base Schiff belonging to the carbohydrate (via intramolecular CNHO-Ar known as "imine clip") or with the hydroxyl groups belonging to the clay surface (via intermolecular Si-OHO-Ar). The exfoliated clay nanoparticles within the carbohydrate polymer enables either accelerating or slowing down of the imine (CN) hydrolysis depending on the interaction of the conjugated aromatics. This provides the driving force for fine tuning host-guest interactions at the molecular level and constitutes an entry toward subtle discrimination of different chemicals (e.g. complementary fertilizers, synergistic drugs) during their sequential release.
协同和/或互补化学品（例如：药物）的时控释放被认为极具挑战性，因为它们的动力学传递常常相互交织，而目前，在公开文献中缺乏能够规避这一瓶颈的简单概念。在这个框架中，我们在此报告了醛基功能化的透明和柔性壳聚糖-蒙脱石混合薄膜，它们作为新一代环保、可控化学释放的生物塑料。这些动态组装的纳米材料是通过生物废料衍生的甲壳素生物聚合物、芳醛和层状粘土纳米粒子的三元组装设计而成的。根据它们的几何和构象特性，接枝芳烃上的含氧基团优先与碳水化合物的碱基席夫碱（通过称为“亚胺夹”的分子内 CNHO-Ar）或粘土表面的羟基（通过分子间 Si-OHO-Ar）相互作用。碳水化合物聚合物内的剥离粘土纳米粒子可以加速或减缓亚胺（CN）水解，具体取决于共轭芳烃的相互作用。这为在分子水平上精细调整主客体相互作用提供了动力，并为在它们的顺序释放过程中对不同化学品（例如互补肥料、协同药物）进行细微区分提供了一种方法。
