College of Textile and Garments, Southwest University, Chongqing 400715, China.
College of Textile and Garments, Southwest University, Chongqing 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China.
Carbohydr Polym. 2018 Mar 1;183:70-80. doi: 10.1016/j.carbpol.2017.11.029. Epub 2017 Nov 10.
A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms. In vitro cytocompatibility testing showed that L929 cells could survive well in the presence of KGM/AgNPs, indicating that KGM/AgNPs have good cytocompatibility. Animal models showed that the KGM/AgNP composite sponges effectively accelerated wound healing, and histological findings showed that they promoted fibroblast growth and accelerated epithelialization. The experimental results showed that KGM/AgNP composite sponges have great potential in promoting wound healing.
一种新型的魔芋葡甘聚糖/银纳米粒子（KGM/AgNP）复合海绵通过简单的两步法成功制备，可作为医用伤口愈合材料。首先，使用绿色还原剂蛋清制备 AgNPs。然后，将 KGM 粉末加入 AgNP 溶液中并剧烈搅拌，通过冷冻干燥得到复合海绵。KGM/AgNP 复合海绵具有优异的吸水性和保水性，以及相当可观的机械性能。KGM/AgNP 复合海绵对测试微生物表现出良好的抗菌活性。体外细胞相容性测试表明，L929 细胞在存在 KGM/AgNPs 的情况下能够良好存活，表明 KGM/AgNPs 具有良好的细胞相容性。动物模型表明，KGM/AgNP 复合海绵能有效促进伤口愈合，组织学研究结果表明，它促进成纤维细胞生长并加速上皮化。实验结果表明，KGM/AgNP 复合海绵在促进伤口愈合方面具有巨大的潜力。
