State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210096, PR China; The Jiangsu Province Research Institute for Clinical Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, PR China.
Research Centre of Clinical Oncology, Jiangsu Cancer Hospital, Nanjing 210009, PR China.
Colloids Surf B Biointerfaces. 2018 Mar 1;163:379-384. doi: 10.1016/j.colsurfb.2018.01.010. Epub 2018 Jan 11.
Herein we reported Prussian blue nanoparticles (PBNPs) possess ascorbic acid oxidase (AAO)- and ascorbic acid peroxidase (APOD)-like activities, which suppressed the formation of harmful HO and finally inhibited the anti-cancer efficiency of ascorbic acid (AA). This newly revealed correlation between iron and AA could provide new insight for the studies of nanozymes and free radical biology.
在此，我们报道普鲁士蓝纳米颗粒（PBNPs）具有抗坏血酸氧化酶（AAO）和抗坏血酸过氧化物酶（APOD）样活性，抑制了有害 HO 的形成，最终抑制了抗坏血酸（AA）的抗癌效率。铁与 AA 之间的这种新发现的相关性可为纳米酶和自由基生物学的研究提供新的见解。
