Liu Xin, Wang Nan, Liu Xiyu, Deng Rongrong, Kang Ran, Xie Lin
Third School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.
Pharmaceutics. 2022 Jul 8;14(7):1433. doi: 10.3390/pharmaceutics14071433.
Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.
在过去几十年中,磁性纳米颗粒(MNPs)因其独特的磁响应性而备受关注。特别是在疾病的诊断和治疗中,它们大多以非侵入性方式参与,并取得了良好的效果。MNPs的磁响应性受到合成颗粒的尺寸、结晶度、均匀性和表面性质的严格控制。在本综述中,我们总结了MNPs的分类及其在血管修复中的应用。MNPs主要利用其独特的磁性参与血管修复,包括磁刺激、磁驱动、磁共振成像、磁热疗、磁组装支架和磁靶向药物递送,这些可显著影响支架性能、细胞行为、因子分泌、药物释放等。尽管MNPs在大规模临床应用中仍存在挑战,但其以良好的非侵入性方式参与血管修复并建立连续检测过程仍是未来的发展方向。