De Waele M, Naessens A, Foulon W, van Camp B
Clin Exp Immunol. 1985 Nov;62(2):256-61.
The mononuclear cells in the peripheral blood of 17 adults with acute phase toxoplasmosis were characterized with monoclonal antibodies. The absolute number of lymphocytes was increased by the presence of high numbers of T-cells with a surface phenotype of T-cytotoxic/suppressor cells (OKT3+, OKT8+). Shortly after the onset of the infection these cells expressed activation antigens (OKT10+, OKIa+). These changes were more pronounced in patients with lymphadenopathy, but were also present in those without symptoms of the disease. The activation antigens disappeared in the first weeks after onset of the disease but the reversed OKT4/OKT8 ratio persisted for 2 to 4 months. It generally normalized in parallel with clinical recovery of the patients. In one patient, however, a reversed OKT4/OKT8 ratio was present for more than 1 year after the disappearance of the symptoms.
用单克隆抗体对17例急性期弓形虫病成人患者外周血中的单核细胞进行了特征分析。淋巴细胞的绝对数量因大量具有细胞毒性/抑制性T细胞表面表型（OKT3 +、OKT8 +）的T细胞的存在而增加。感染开始后不久，这些细胞表达激活抗原（OKT10 +、OKIa +）。这些变化在有淋巴结病的患者中更为明显，但在没有疾病症状的患者中也存在。激活抗原在疾病发作后的最初几周消失，但OKT4/OKT8比值倒置持续2至4个月。它通常随着患者的临床康复而恢复正常。然而，在一名患者中，症状消失后1年多仍存在OKT4/OKT8比值倒置的情况。
