Welch P C, Masur H, Jones T C, Remington J S
J Infect Dis. 1980 Aug;142(2):256-64. doi: 10.1093/infdis/142.2.256.
The diagnosis of acute toxoplasmosis usually depends on serology, yet little data are available to compare the relative usefulness of various serologic tests after the onset of illness. The Sabin-Feldman dye test (DT), the IgM immunofluorescent antibody (IgM-IFA) test, the soluble antigen complement-fixation (CF) test, and the indirect hemagglutination (IHA) test were performed on serial serum specimens from 27 previously healthy patients, each of whom could identify the date of onset of illness within two weeks. IgM-IFA titers of greater than or equal to 1:160 were the best indicators of infection acquired in the past two to four months. The DT was useful for screening, but two-tube rises in titer were rarely documented, and absolute titers were imprecise indicators of the recentness of infection. Although two-tube rises in titer in CF and IHA tests could be seen in the majority of patients, the rises were so slow that both tests were less useful than the IgM-IFA test in documenting the diagnosis of acute toxoplasmosis.
急性弓形虫病的诊断通常依赖于血清学检测，然而在疾病发作后，几乎没有数据可用于比较各种血清学检测的相对效用。对27名既往健康的患者的系列血清标本进行了Sabin - Feldman染色试验（DT）、IgM免疫荧光抗体（IgM - IFA）试验、可溶性抗原补体结合试验（CF）和间接血凝试验（IHA），每名患者都能在两周内确定疾病发作日期。IgM - IFA滴度大于或等于1:160是过去两到四个月内获得感染的最佳指标。DT可用于筛查，但很少记录到滴度升高两管的情况，且绝对滴度并非感染近期性的精确指标。尽管在大多数患者中CF和IHA试验可见滴度升高两管的情况，但升高非常缓慢，以至于在诊断急性弓形虫病时，这两种试验都不如IgM - IFA试验有用。
