The sensation of disrupted sleep following ascent to high altitude is associated with frequent awakenings, which may reflect sleep disruption due to respiratory dysrhythmia consisting typically of monotonously repetitive periodic breathing. This seems to arise from the combined effects of hypocapnia, which leads to suppression of respiratory effort in NREM sleep, and hypoxia, which stimulates termination of apnea and hyperpnea with consequent hypocapnia, leading to perpetuation of periodicity. Sleep disruption and periodic breathing decrease with time at altitude but may also be considerably reduced by pretreatment with acetazolamide, which may act by correction of alkalosis or through some other mechanism. In long-term residents of high altitude less distinctive, undulating respiratory dysrhythmias are described with unstable and decreased arterial oxygenation.
ascent to high altitude is associated with frequent awakenings, which may reflect sleep disruption due to respiratory dysrhythmia consisting typically of monotonously repetitive periodic breathing. This seems to arise from the combined effects of hypocapnia, which leads to suppression of respiratory effort in NREM sleep, and hypoxia, which stimulates termination of apnea and hyperpnea with consequent hypocapnia, leading to perpetuation of periodicity. Sleep disruption and periodic breathing decrease with time at altitude but may also be considerably reduced by pretreatment with acetazolamide, which may act by correction of alkalosis or through some other mechanism. In long-term residents of high altitude less distinctive, undulating respiratory dysrhythmias are described with unstable and decreased arterial oxygenation.
登高后睡眠中断的感觉与频繁觉醒有关，这可能反映了由呼吸节律不齐导致的睡眠中断，呼吸节律不齐通常表现为单调重复的周期性呼吸。这似乎是由低碳酸血症和低氧血症的联合作用引起的，低碳酸血症会导致非快速眼动睡眠中呼吸努力的抑制，而低氧血症会刺激呼吸暂停和呼吸急促的终止，从而导致低碳酸血症，进而导致周期性的持续。随着在高原停留时间的增加，睡眠中断和周期性呼吸会减少，但用乙酰唑胺预处理也可能会显著降低，乙酰唑胺可能通过纠正碱中毒或其他机制起作用。在长期居住在高原的人群中，会出现不太明显的、起伏不定的呼吸节律不齐，伴有不稳定和降低的动脉氧合。
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