Goldenberg F, Richalet J P, Onnen I, Antezana A M
Laboratoire de sommeil, CHU Henri Mondor, Créteil, France.
Int J Sports Med. 1992 Oct;13 Suppl 1:S34-6. doi: 10.1055/s-2007-1024586.
Sleep and respiration data from two French medical high altitude expeditions (Annapurna 4,800 m and Mt Sajama 6,542 m) are presented. Difficulties in maintaining sleep and a SWS decrease were found with periodic breathing (PB) during both non-REM and REM sleep. Extent of PB varied considerably among subjects and was not correlated to the number of arousals but to the intercurrent wakefulness duration. There was a positive correlation between the time spent in PB and the individual hypoxic ventilatory drive. The relation between PB, nocturnal desaturation, and mountain sickness intensity are discussed. Acclimatization decreased the latency toward PB and improved sleep. Hypnotic benzodiazepine intake (loprazolam 1 mg) did not worsen either SWS depression or apneas and allowed normal sleep reappearance after acclimatization.
本文展示了来自两次法国医学高海拔探险（安纳布尔纳峰4800米和萨哈马峰6542米）的睡眠和呼吸数据。在非快速眼动睡眠和快速眼动睡眠期间，发现周期性呼吸（PB）会导致维持睡眠困难和慢波睡眠减少。PB的程度在受试者之间差异很大，与觉醒次数无关，但与间歇性清醒持续时间有关。PB持续时间与个体低氧通气驱动之间存在正相关。讨论了PB、夜间去饱和与高山病强度之间的关系。适应可减少PB的潜伏期并改善睡眠。服用催眠性苯二氮䓬类药物（氯普唑仑1毫克）既不会加重慢波睡眠抑制或呼吸暂停，也能在适应后使睡眠恢复正常。
