Zhang Jiaxiang, Zhu Yong, Wang Ruilan
Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Histol Histopathol. 2018 Aug;33(8):747-756. doi: 10.14670/HH-11-966. Epub 2018 Jan 22.
Recently developed RNA microarrays and high-throughput sequencing techniques have demonstrated that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes. Emerging evidence has confirmed the relevance of lncRNAs to diverse types of human disease, including cancer and cardiovascular disease. In this review, we discuss the important functions of lncRNAs in respiratory diseases. Because the reviewed studies have mainly focused on non-small cell lung cancer, future work will need to extend the studies into other respiratory diseases. From a clinical perspective, targeting lncRNAs as a novel therapeutic strategy in respiratory diseases will require further study to further clarify their biological functions.
最近开发的RNA微阵列和高通量测序技术表明，长链非编码RNA（lncRNA）在广泛的生物过程中发挥着重要作用。新出现的证据证实了lncRNA与多种人类疾病的相关性，包括癌症和心血管疾病。在这篇综述中，我们讨论了lncRNA在呼吸系统疾病中的重要功能。由于所综述的研究主要集中在非小细胞肺癌上，未来的工作需要将研究扩展到其他呼吸系统疾病。从临床角度来看，将lncRNA作为呼吸系统疾病的一种新型治疗策略需要进一步研究，以进一步阐明其生物学功能。
