Wang Chong, Huang Haiyun, Wang Hongyu, Li Chunying, Liu Xiaoling
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Mar;36(3):233-238. doi: 10.13201/j.issn.2096-7993.2022.03.016.
Long non-coding RNA（lncRNA） belongs to the category of non-coding RNA, which length exceeds 200 nucleotides and can hardly encode the expression of proteins. Based on the data from several clinical researches, it is considered that lncRNA not only plays the biological role in epigenetics, transcriptional and post-transcriptional levels, but also abnormally expresses in inflammatory response and the related diseases. In recent years, with the intensive study of gene expression regulation of allergic rhinitis（AR）, it has been found that a variety of non-coding RNA, including lncRNA, have close relationship with the occurrence and development of AR. This review mainly summarized the biological function, immunomodulatory effect of lncRNA and the relationship between the lncRNA and the pathogenesis of AR, providing new thoughts and strategies for the further research, prevention as well as the treatment of AR.
长链非编码RNA（lncRNA）属于非编码RNA类别，其长度超过200个核苷酸，几乎不能编码蛋白质的表达。基于多项临床研究的数据，认为lncRNA不仅在表观遗传学、转录和转录后水平发挥生物学作用，而且在炎症反应及相关疾病中异常表达。近年来，随着对变应性鼻炎（AR）基因表达调控的深入研究，发现包括lncRNA在内的多种非编码RNA与AR的发生发展密切相关。本文综述主要总结了lncRNA的生物学功能、免疫调节作用以及lncRNA与AR发病机制的关系，为AR的进一步研究、预防及治疗提供新的思路和策略。
