苦参根中的五种新生物碱。
Five New Alkaloids from the Roots of Sophora flavescens.
作者信息
Zhang Sheng-Yuan, Li Wen, Nie Hua, Liao Mei, Qiu Bo, Yang Ya-Li, Chen Yan-Fen
机构信息
Medical College of Jiaying University, Meizhou, 514031, P. R. China.
Guangdong Province Hospital of TCM, Guangzhou, 510000, P. R. China.
出版信息
Chem Biodivers. 2018 Mar;15(3):e1700577. doi: 10.1002/cbdv.201700577.
Five new quinolizidine alkaloids, including three sparteine-type alkaloids (1 - 3) and two cytisine-type alkaloids (4 and 5), along with four known ones, were isolated from the roots of Sophora flavescens. Their structures were determined by extensive spectroscopic techniques including IR, UV, NMR, and HR-ESI-MS. All the compounds were evaluated for their antibacterial activities against Staphylococcus aureus and Escherichia coli.
从苦参根部分离出了5种新的喹诺里西啶生物碱，包括3种鹰爪豆碱型生物碱（1 - 3）和2种金雀花碱型生物碱（4和5），以及4种已知生物碱。通过红外光谱（IR）、紫外光谱（UV）、核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）等多种光谱技术确定了它们的结构。对所有化合物进行了针对金黄色葡萄球菌和大肠杆菌的抗菌活性评估。
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