Karim Safae, Souho Tiatou, Benlemlih Mohamed, Bennani Bahia
Laboratory of Microbiology and Molecular Biology, Faculty of Medicine and Pharmacy of Fez (FMPF), Sidi Mohammed Ben Abdellah University (USMBA), Fez, Morocco.
Laboratory of Biotechnologies, Faculty of Sciences Dhar El Mahraz, USMBA, Fez, Morocco.
Curr Microbiol. 2018 Dec;75(12):1667-1674. doi: 10.1007/s00284-018-1439-7. Epub 2018 Jan 22.
Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Chlamydia trachomatis the most common bacterial sexually transmitted infection is often asymptomatic but causes various syndromes such as cervicitis, endometritis, pelvic inflammatory disease, and infertility. It is established that this bacterium is involved in cell proliferation process and inhibit apoptosis. Furthermore, C. trachomatis may induce chronic inflammation, interfere with immune response by decreasing the number of antigen presenting cells, and reduce the cell-mediated immunity allowing the persistence of HPV. However, it is unclear whether this bacterium plays a particular role in cervical cancer induction. We therefore aimed at enlightening the actual knowledge about the relationship between C. trachomatis and cervical cancer or precursor lesions through a systematic literature review. We summarized and analyzed the epidemiological data on C. trachomatis and its co-infection with HPV and their association to cervical cancer.
人乳头瘤病毒（HPV）持续感染是宫颈癌发生的必要但不充分条件。还需要其他协同因素来诱导细胞转化，进而发展为恶性宫颈癌。这些协同因素包括物理因素、其他性传播感染以及免疫反应。沙眼衣原体是最常见的细菌性传播感染病原体，通常无症状，但可引发多种综合征，如宫颈炎、子宫内膜炎、盆腔炎和不孕症。现已证实，这种细菌参与细胞增殖过程并抑制细胞凋亡。此外，沙眼衣原体可能诱发慢性炎症，通过减少抗原呈递细胞数量干扰免疫反应，并降低细胞介导的免疫，从而使HPV得以持续存在。然而，尚不清楚这种细菌在宫颈癌诱发过程中是否发挥特定作用。因此，我们旨在通过系统的文献综述来阐明关于沙眼衣原体与宫颈癌或癌前病变之间关系的现有知识。我们总结并分析了沙眼衣原体及其与HPV合并感染的流行病学数据，以及它们与宫颈癌的关联。
