Takaya Yukiko, Matsubayashi Hidehiko, Kitaya Kotaro, Nishiyama Rie, Yamaguchi Kohei, Takeuchi Takumi, Ishikawa Tomomoto
Reproduction Clinic Osaka, 15F, Grand Front Osaka Tower A4-20 Ofukacho, Kita, Osaka, 530-0011, Japan.
BMC Res Notes. 2018 Jan 22;11(1):61. doi: 10.1186/s13104-018-3188-x.
The aim of the study was to assess the lower limits of midluteal plasma progesterone and estradiol concentrations in patients who achieved pregnancy with timed intercourse or intrauterine insemination without a human menopausal gonadotropin stimulation.
We included 297 pregnant cycles of 297 women and assessed midluteal plasma progesterone and estradiol concentrations and pregnancy outcomes, retrospectively. These cycles were compared with the non-pregnant cycles (406 cycles) of the same women who became pregnant. Mean midluteal plasma P4 and E2 concentrations were significantly (P < 0.01) higher in pregnant cycles (14.5 and 188.5 pg/mL) than in non-pregnant cycles (10.7 and 162.6 pg/mL). The 5 percentiles of progesterone and estradiol in pregnant cycles were 5.6 and 70.2 pg/mL, respectively. The lowest progesterone and estradiol levels in pregnant cycles were 2.3 and 23.4 pg/mL, respectively. In non-pregnant cycles, many women had low P4 levels that were less than 5.6 ng/mL. Subgroup analyses showed slight differences among the four groups, which may have been due to the ovarian function of each group. Miscarriage was not related to progesterone and estradiol concentrations. These values may be useful for the evaluation of necessary values for pregnancy with timed intercourse or intrauterine insemination.
本研究旨在评估在未使用人绝经期促性腺激素刺激的情况下，通过定时性交或宫内人工授精成功受孕的患者黄体中期血浆孕酮和雌二醇浓度的下限。
我们纳入了297名女性的297个妊娠周期，回顾性评估了黄体中期血浆孕酮和雌二醇浓度以及妊娠结局。将这些周期与同一女性随后怀孕的非妊娠周期（406个周期）进行比较。妊娠周期中黄体中期血浆P4和E2的平均浓度（分别为14.5和188.5 pg/mL）显著高于非妊娠周期（分别为10.7和162.6 pg/mL）（P<0.01）。妊娠周期中孕酮和雌二醇的第5百分位数分别为5.6和70.2 pg/mL。妊娠周期中孕酮和雌二醇的最低水平分别为2.3和23.4 pg/mL。在非妊娠周期中，许多女性的P4水平低于5.
