Usala Stephen J, Alliende María Elena, Trindade A Alexandre
Department of Internal Medicine, Texas Tech University Health Sciences Center, 1400 S. Coulter Street, Amarillo, TX 79106, USA.
Programa de Cuidado y Estudio de la Fertilidad (PROCEF), Departamento de Obstetricia, Ginecología y Biología de la, Reproducción, Universidad de los Andes, Monseñor Alvaro del Portillo 12455, Santiago 7620001, Chile.
Medicina (Kaunas). 2021 Feb 3;57(2):134. doi: 10.3390/medicina57020134.
: The Fertility Indicator Equation (FIE) has been shown to signal the fertile phase during the ovulatory menstrual cycle. It was hypothesized that this formulation, a product of two sequential normalized changes with a sign indicating direction of change, could be used to identify the transition from ovulatory to luteal phase with daily serum progesterone (P) and urinary pregnanediol-3-glucuronide (PDG) levels. : Day-specific serum P levels from two different laboratories and day-specific urinary PDG levels from an additional two different laboratories were submitted for FIE analysis. These day-specific levels included mean or median, 5th, 10th, 90th and 95th percentile data. They were indexed to the day of ovulation, day 0, by ultrasonography, serum or urinary luteinizing hormone (LH). : All data sets showed a clear "cluster"-a periovulatory sequence of positive FIE values with a maximum. All clusters of +FIE signaled the transition from the ovulatory to luteal phase and were at least four days in length. The start day for the serum P and urinary PDG FIE clusters ranged from -3 to -1 and -3 to +2, respectively. The end day for serum P and PDG clusters went from +2 to +7 and +4 to +8, respectively. Outside these periovulatory FIE-P and FIE-PDG clusters, there were no consecutive positive FIE values. In addition, the maximum FIE-P and FIE-PDG values throughout the entire cycles were found in the clusters. : FIE analysis with either daily serum P or urinary PDG levels provided a distinctive signature to recognize the periovulatory interval. The Fertility Indicator Equation served to robustly signal the transition from the ovulatory phase to the luteal phase. This may have applications in natural family planning especially with the recent emergence of home PDG tests.
生育指标方程（FIE）已被证明可在排卵性月经周期中指示可育期。据推测，这种由两个连续的标准化变化（其符号指示变化方向）组成的公式，可用于根据每日血清孕酮（P）和尿孕二醇 - 3 - 葡萄糖醛酸苷（PDG）水平来识别从排卵期到黄体期的转变。：来自两个不同实验室的特定日期血清P水平以及另外两个不同实验室的特定日期尿PDG水平被提交用于FIE分析。这些特定日期的水平包括均值或中位数、第5、10、90和95百分位数数据。通过超声检查、血清或尿促黄体生成素（LH）将它们以排卵日（第0天）为索引。：所有数据集均显示出明显的“聚类”——FIE值为正的围排卵期序列且有一个最大值。所有FIE为正的聚类均指示从排卵期到黄体期的转变，且长度至少为四天。血清P和尿PDG的FIE聚类的起始日分别为 - 3至 - 1和 - 3至 + 2。血清P和PDG聚类的结束日分别为 + 2至 + 7和 + 4至 + 8。在这些围排卵期的FIE - P和FIE - PDG聚类之外，不存在连续的正FIE值。此外，在整个周期中，FIE - P和FIE - PDG的最大值出现在这些聚类中。：使用每日血清P或尿PDG水平进行FIE分析可提供一种独特的特征来识别围排卵期。生育指标方程可有力地指示从排卵期到黄体期的转变。这可能在自然计划生育中有应用，特别是鉴于最近家庭用PDG检测的出现。
