Pernice Wolfgang M, Swayne Theresa C, Boldogh Istvan R, Pon Liza A
Department of Pathology and Cell Biology, Columbia University, New York, NY, United States.
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, United States.
Front Cell Dev Biol. 2018 Jan 8;5:120. doi: 10.3389/fcell.2017.00120. eCollection 2017.
Tethers that link mitochondria to other organelles are critical for lipid and calcium transport as well as mitochondrial genome replication and fission of the organelle. Here, we review recent advances in the characterization of interorganellar mitochondrial tethers in the budding yeast, . We specifically focus on evidence for a role for mitochondrial tethers that anchor mitochondria to specific regions within yeast cells. These tethering events contribute to two processes that are critical for normal replicative lifespan: inheritance of fitter mitochondria by daughter cells, and retention of a small pool of higher-functioning mitochondria in mother cells. Since asymmetric inheritance of mitochondria also occurs in human mammary stem-like cells, it is possible that mechanisms underlying mitochondrial segregation in yeast also operate in other cell types.
将线粒体与其他细胞器连接起来的系链对于脂质和钙的运输、线粒体基因组复制以及细胞器的分裂至关重要。在此，我们综述了出芽酵母中细胞器间线粒体系链特征的最新进展。我们特别关注线粒体系链将线粒体锚定到酵母细胞内特定区域的作用证据。这些系链事件促成了两个对正常复制寿命至关重要的过程：子细胞继承更健康的线粒体，以及母细胞中保留一小部分功能更高的线粒体。由于线粒体的不对称遗传也发生在人乳腺干细胞样细胞中，酵母中线粒体分离的潜在机制也可能在其他细胞类型中起作用。
