通过多模态成像研究含铼三羰基标记物的透明质酸的经皮渗透。
Labeling of Hyaluronic Acids with a Rhenium-tricarbonyl Tag and Percutaneous Penetration Studied by Multimodal Imaging.
机构信息
Laboratoire des biomolécules, LBM, Département de chimie, École normale supérieure , PSL University, Sorbonne Université, CNRS , 75005 Paris , France.
Laboratory of Analytical Chemistry, Lip(Sys)2, (EA 7357), Faculty of Pharmacy, Paris-Sud , University of Paris-Saclay , 5 Rue Jean-Baptiste Clément , 92296 Chatenay-Malabry , France.
出版信息
Bioconjug Chem. 2018 Apr 18;29(4):987-991. doi: 10.1021/acs.bioconjchem.7b00825. Epub 2018 Feb 22.
Hyaluronic acids were labeled with a rhenium-tricarbonyl used as single core multimodal probe for imaging and their penetration into human skin biopsies was studied using IR microscopy and fluorescence imaging (labeled SCoMPI). The penetration was shown to be dependent on the molecular weight of the molecule and limited to the upper layer of the skin.
透明质酸被一种用作单核多模式探针的铼三羰基标记，用于使用红外显微镜和荧光成像（标记 SCoMPI）研究其穿透人体皮肤活检。结果表明，穿透深度取决于分子的分子量，并仅限于皮肤的上层。
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