Lorigo Margarida, Mariana Melissa, Cairrao Elisa
CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
CICS-UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Steroids. 2018 Mar;131:46-58. doi: 10.1016/j.steroids.2018.01.006. Epub 2018 Jan 31.
The Ultraviolet (UV) radiation is emitted by the sun and is part of the electromagnetic spectrum. There are three types of UV rays (UV-A, UV-B and UV-C), however only UV-A and UV-B have biologic effects in humans, with UV-B radiation being primarily responsible for these effects. Among the measures of photoprotection advised by the health authorities, the topical application of sunscreens (containing UV-B filters) is the preferred worldwide. Currently, octylmethoxycinnamate (OMC) is the most commonly used UV-B filter in sunscreens. Their application has proven to be effective in preventing burns, but its efficiency against melanoma continues under intense controversy. Studies have shown that OMC behaves like an endocrine disruptor, altering the normal functioning of organisms. However, few studies have evaluated their multiple hormonal activities. Some studies suggest that the OMC exerts an estrogenic, anti-androgenic, anti-progestenic and anti-thyroid activity. But, through what mechanisms? In humans, few studies were performed, and some questions remain unclear. Thus, the purpose of this review is to present the multiple hormonal activities established for the OMC, making a critical analysis and relationship between the effects in cells, animals and humans.
紫外线（UV）辐射由太阳发出，是电磁光谱的一部分。紫外线有三种类型（UV-A、UV-B和UV-C），然而，只有UV-A和UV-B对人类具有生物学效应，其中UV-B辐射是产生这些效应的主要原因。在卫生当局建议的光防护措施中，局部涂抹防晒霜（含UV-B滤光剂）是全球范围内的首选方法。目前，桂皮酸盐（OMC）是防晒霜中最常用的UV-B滤光剂。其应用已被证明在预防晒伤方面有效，但其对黑色素瘤的预防效果仍存在激烈争议。研究表明，OMC表现得像一种内分泌干扰物，会改变生物体的正常功能。然而，很少有研究评估其多种激素活性。一些研究表明，OMC具有雌激素、抗雄激素、抗孕激素和抗甲状腺活性。但是，其作用机制是什么呢？在人类身上，相关研究很少，一些问题仍不明确。因此，本综述的目的是介绍已确定的OMC的多种激素活性，并对其在细胞、动物和人类中的作用进行批判性分析和关联。
