Maternal, Fetal, and Newborn Research Center, Tehran University of Medical Sciences, Vali-e-Asr Hospital, Keshavarz Bul., Tehran, 1419733141, Iran; Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Maternal Nursing, Division of Nursing, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8543, Japan.
Reprod Toxicol. 2018 Mar;76:78-83. doi: 10.1016/j.reprotox.2018.01.002. Epub 2018 Jan 31.
Adverse effects of prenatal mercury exposure on pregnancy outcomes remain a public health concern. We assessed the relationship between prenatal mercury exposure and newborn anthropometric characteristics in 334 mother-child pairs from the early stages of pregnancy to delivery in Tokyo, Japan, between December 2010 and October 2012. We found a negative correlation between blood mercury levels during the first and second trimesters of gestation and birth weight (r = -0.134 and -0.119, respectively; p < 0.05). Multiple linear regression analysis confirmed the relationship between first-trimester maternal blood mercury levels and birth weight when adjusted for independent variables (β = -0.170, t = -2.762; p = 0.006). Mean mercury levels in umbilical cord blood were twice as high as maternal blood levels (10.15 ± 7.74 and 4.97 ± 3.25 μg/L, respectively; r = 0.974, p < 0.001). Our findings suggest that pregnant women and women of reproductive age should avoid mercury exposure, even at low levels, because of its potentially adverse effects on fetal development.
产前汞暴露对妊娠结局的不良影响仍然是一个公共卫生关注点。我们评估了日本东京 334 对母婴在妊娠早期到分娩期间的汞暴露与新生儿人体测量特征之间的关系。我们发现妊娠前 2 个三个月的血汞水平与出生体重呈负相关（r = -0.134 和 -0.119，分别；p < 0.05）。多元线性回归分析在调整了自变量后证实了母亲血汞水平与出生体重之间的关系（β = -0.170，t = -2.762；p = 0.006）。脐带血中的汞平均水平是母体血液水平的两倍（分别为 10.15 ± 7.74 和 4.97 ± 3.25 μg/L；r = 0.974，p < 0.001）。我们的研究结果表明，孕妇和育龄妇女应避免接触汞，即使是低水平的汞，因为它可能对胎儿发育产生不良影响。
