Walejko Jacquelyn M, Chelliah Anushka, Keller-Wood Maureen, Gregg Anthony, Edison Arthur S
Department of Biochemistry & Molecular Biology, University of Florida, Gainesville, FL 32610, USA.
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center at Houston, UT Health, Houston, TX 77030, USA.
Metabolites. 2018 Jan 23;8(1):10. doi: 10.3390/metabo8010010.
We evaluated the metabolic alterations in maternal and fetal placental tissues from non-labored women undergoing cesarean section using samples collected from 5 min to 24 h following delivery. Using ¹H-NMR, we identified 14 metabolites that significantly differed between maternal and fetal placental tissues (FDR-corrected -value < 0.05), with 12 metabolites elevated in the maternal tissue, reflecting the flux of these metabolites from mother to fetus. In the maternal tissue, 4 metabolites were significantly altered at 15 min, 10 metabolites at 30 min, and 16 metabolites at 1 h postdelivery, while 11 metabolites remained stable over 24 h. In contrast, in the fetal placenta tissue, 1 metabolite was significantly altered at 15 min, 2 metabolites at 30 min, and 4 metabolites at 1 h postdelivery, while 22 metabolites remained stable over 24 h. Our study provides information on the metabolic profiles of maternal and fetal placental tissues delivered by cesarean section and reveals that there are different metabolic alterations in the maternal and fetal tissues of the placenta following delivery.
我们使用分娩后5分钟至24小时收集的样本，评估了接受剖宫产的未临产妇女的母体和胎儿胎盘组织中的代谢变化。使用¹H-NMR，我们鉴定出14种在母体和胎儿胎盘组织之间有显著差异的代谢物（FDR校正P值<0.05），其中12种代谢物在母体组织中升高，反映了这些代谢物从母亲到胎儿的通量。在母体组织中，4种代谢物在产后15分钟有显著变化，10种代谢物在30分钟有显著变化，16种代谢物在产后1小时有显著变化，而11种代谢物在24小时内保持稳定。相比之下，在胎儿胎盘组织中，1种代谢物在产后15分钟有显著变化，2种代谢物在30分钟有显著变化，4种代谢物在产后1小时有显著变化，而22种代谢物在24小时内保持稳定。我们的研究提供了关于剖宫产分娩的母体和胎儿胎盘组织代谢谱的信息，并揭示了分娩后胎盘的母体和胎儿组织存在不同的代谢变化。
