Dalianis Georgios, Trivli Alexandra, Terzidou Chryssa
Department of Ophthalmology, Konstantopouleio-Patission General Hospital, Agias Olgas 3-5, Nea Ionia, 14233 Athens, Greece.
Medicines (Basel). 2018 Jan 22;5(1):12. doi: 10.3390/medicines5010012.
We aimed to investigate the clinical importance of conjunctivochalasis (CCH) and, further, to implement a new CCH classification system. 60 eyes of patients with whom, upon clinical examination, CCH was diagnosed were investigated for the presence of symptoms and signs characteristic of dry eye. The eyes were grouped based on two stages of severity, Stage 1 (minimal/mild) and Stage 2 (medium/severe), for each nasal, middle, and temporal position, and on the extent of CCH folds in each site. In 40 (66.6%) out of 60 eyes, symptoms and signs of CCH were manifest: pain in 25 (41.6%), epiphora in 25 (41.6%), and lacrimal punctum obstruction from conjunctival folds in 22 (36.6%) eyes. Depending on the position of CCH, a greater percentage of symptoms appeared in Stage 2 in the nasal position (78.9%), followed by middle (68.7%) and temporal positions (60%). When TBUT values were compared, statistically significant differences were found proportional to grading ( < 0.001) and position (nasal more severe than temporal, < 0.001), and such differences were also found when TBUT values of all eyes were compared with those of symptomatic eyes ( = 0.01) and with those of symptom-free eyes ( = 0.002). CCH is a rather frequent and commonly unrecognized condition that should always be considered in differential diagnoses of dry eye.
我们旨在研究结膜松弛症(CCH)的临床重要性,并进一步实施一种新的CCH分类系统。对60例经临床检查诊断为CCH的患者的眼睛进行了干眼特征性症状和体征的调查。根据严重程度的两个阶段,即1期(轻度/轻微)和2期(中度/重度),对每个鼻侧、中间和颞侧位置以及每个部位CCH褶皱的范围对眼睛进行分组。60只眼中有40只(66.6%)出现了CCH的症状和体征:25只眼(41.6%)疼痛,25只眼(41.6%)溢泪,22只眼(36.6%)因结膜褶皱导致泪小点阻塞。根据CCH的位置,2期鼻侧位置出现症状的百分比更高(78.9%),其次是中间位置(68.7%)和颞侧位置(60%)。比较泪膜破裂时间(TBUT)值时,发现与分级(<0.001)和位置(鼻侧比颞侧严重,<0.001)成比例的统计学显著差异,并且在将所有眼睛的TBUT值与有症状眼睛的TBUT值(=0.01)和无症状眼睛的TBUT值(=0.002)进行比较时也发现了这种差异。CCH是一种相当常见且常未被认识的病症,在干眼的鉴别诊断中应始终予以考虑。