Bayoumi R A, Bashir A H, Abdulhadi N H
Am J Trop Med Hyg. 1986 Jan;35(1):45-55. doi: 10.4269/ajtmh.1986.35.45.
Adults claiming resistance to malaria were identified in the Sennar region of central Sudan, where P. falciparum is hyperendemic but seasonal in transmission. Indirect fluorescent antibody (IFA) titers of sera from these individuals were comparable to those of malaria patients with positive blood films, indicating equal exposure, while in vitro antiparasitic activity of their sera tended to be higher, indicating an effective immunological response to falciparum malaria. Hemoglobin S (Hb S) was significantly more prevalent in adults resistant to malaria. This trait offers protection at the erythrocyte level and it is also possible that it could enhance the ability of carrier adults to acquire protective immunity. Erythrocyte 6-phosphogluconate dehydrogenase A (PGDA) and phosphoglucomutase 1 (PGM1), phenotypes of unknown relevance to protection against falciparum malaria, were also significantly more prevalent in those claiming resistance to malaria. A trend of higher prevalence for erythrocyte glucose-6-phosphate dehydrogenase deficiency (G6PD-), Kell (+) and transferrin D (TfD) was detected among resistant individuals and higher KP(a+) and P2 among malaria patients, but the numbers evaluated in this study did not allow determination of statistical significance. No association was found with erythrocyte glyoxalases, ABO and Duffy blood groups and serum haptoglobins.
在苏丹中部森纳尔地区发现了声称对疟疾有抵抗力的成年人，该地区恶性疟原虫高度流行但传播具有季节性。这些个体血清的间接荧光抗体（IFA）滴度与血涂片阳性的疟疾患者相当，表明暴露程度相同，而他们血清的体外抗寄生虫活性往往更高，表明对恶性疟有有效的免疫反应。血红蛋白S（Hb S）在对疟疾有抵抗力的成年人中明显更为普遍。这种特性在红细胞水平提供保护，而且携带该特性的成年人也有可能增强获得保护性免疫的能力。红细胞6 - 磷酸葡萄糖酸脱氢酶A（PGDA）和磷酸葡萄糖变位酶1（PGM1）这两种与抵抗恶性疟的保护作用相关性未知的表型，在声称对疟疾有抵抗力的人群中也明显更为普遍。在有抵抗力的个体中检测到红细胞葡萄糖 - 6 - 磷酸脱氢酶缺乏症（G6PD -）、凯尔血型阳性（Kell(+)）和转铁蛋白D（TfD）的患病率有升高趋势，而在疟疾患者中检测到Kidd血型抗原阳性（KP(a+)）和P2抗原的患病率更高，但本研究评估的数量不足以确定统计学意义。未发现与红细胞乙二醛酶、ABO和达菲血型以及血清触珠蛋白有相关性。
