Jarvis S N, Holloway J S, Hey E N
Arch Dis Child. 1985 Dec;60(12):1113-21. doi: 10.1136/adc.60.12.1113.
A register has been compiled of the 421 children with congenital cerebral palsy born between 1960 and 1975 from a defined geographical area of North East England (population 770 000). There was a fall in the rate of cerebral palsy among very low birthweight babies between 1964 and 1975 and also in the small group with dyskinetic cerebral palsy. The rate rose, however, among babies weighing more than 2.5 kg at birth in the second half of the study, in parallel with changes in perinatal mortality. The net effect is that the overall congenital cerebral palsy rate (mean 1.64 per 1000 livebirths) showed a gradual rise between 1968 and 1975. This conclusion is reinforced by evidence of a rise in incidence among the subgroup of patients with severe cerebral palsy (as defined by an interval measurement of handicap) during the same period.
已编制了一份登记册,记录了1960年至1975年间在英格兰东北部一个特定地理区域(人口77万)出生的421名先天性脑瘫患儿。1964年至1975年间,极低出生体重儿中的脑瘫发病率有所下降,运动障碍型脑瘫的小群体中发病率也有所下降。然而,在研究后半期,出生体重超过2.5千克的婴儿中发病率上升,这与围产期死亡率的变化趋势一致。总体效果是,先天性脑瘫的总体发病率(平均每1000例活产中有1.64例)在1968年至1975年间呈逐渐上升趋势。同一时期重度脑瘫患者亚组(根据残疾间隔测量定义)发病率上升的证据进一步强化了这一结论。