脑瘫与多胞胎
Cerebral palsy and multiple births.
作者信息
Pharoah P O, Cooke T
机构信息
Department of Public Health, University of Liverpool.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1996 Nov;75(3):F174-7. doi: 10.1136/fn.75.3.f174.
AIM
To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births.
METHODS
Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained.
RESULTS
The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins, and 44.8 in triplets. The prevalence of cerebral palsy rose with decreasing birthweight. The birthweight specific prevalence among those of low birthweight < 2500 g was not significantly different in singleton than in multiple births. Among infants weighing > or = 2500 g, there was a significantly higher risk in multiple than in singleton births. The higher crude cerebral palsy prevalence in multiple births is partly due to the lower birthweight distribution and partly due to the higher risk among normal birthweight infants.
CONCLUSIONS
Multiple birth babies are at increased risk of cerebral palsy. There is also an increased risk of cerebral palsy within a twin pregnancy if the co-twin has died in utero.
目的
比较单胎和多胎出生中按出生体重划分的脑瘫患病率。
方法
确定了1982年至1989年期间居住在默西塞德郡和柴郡的母亲所生脑瘫婴儿的登记出生情况。
结果
单胎中脑瘫的粗患病率为每1000名存活婴儿中有2.3例，双胞胎中为12.6例，三胞胎中为44.8例。脑瘫患病率随出生体重降低而上升。出生体重<2500g的低体重儿中，单胎和多胎的按出生体重划分的患病率无显著差异。在体重≥2500g的婴儿中，多胎出生的风险显著高于单胎出生。多胎出生中较高的脑瘫粗患病率部分归因于较低的出生体重分布，部分归因于正常出生体重婴儿中较高的风险。
结论
多胎出生婴儿患脑瘫的风险增加。如果双胎妊娠中的另一胎儿在子宫内死亡，双胎妊娠中患脑瘫的风险也会增加。
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