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脑瘫的出生患病率趋势。

Trends in birth prevalence of cerebral palsy.

作者信息

Pharoah P O, Cooke T, Rosenbloom I, Cooke R W

出版信息

Arch Dis Child. 1987 Apr;62(4):379-84. doi: 10.1136/adc.62.4.379.

DOI:10.1136/adc.62.4.379
PMID:3592729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1778340/
Abstract

A register of children with cerebral palsy born in the period 1966-77 to mothers resident in the Mersey region was compiled from several different data sources. There were 685 cases, with a male:female ratio of 1.4:1. The birth prevalence of cerebral palsy ranged from 1.18 to 1.97 per 1000 live births each year, with a mean of 1.51 per 1000 live births. There was no discernible trend in overall prevalence, but there was a highly significant upward trend in the prevalence of cerebral palsy among low birthweight infants, which was evident for all the major types of cerebral palsy. It is postulated that this is due to improved survival rather than a real change in incidence. Alternatively, because the register was compiled from health service records, a diagnostic access bias from improved follow up of low birthweight infants may have led to an apparent increase in prevalence.

摘要

一份关于1966年至1977年间出生于默西地区、母亲居住在该地区的脑瘫患儿登记册是从几个不同的数据来源汇编而成的。共有685例病例，男女比例为1.4:1。每年每1000例活产中脑瘫的出生患病率在1.18至1.97之间，平均为每1000例活产1.51例。总体患病率没有明显趋势，但低体重儿中脑瘫患病率有极显著的上升趋势，这在所有主要类型的脑瘫中都很明显。据推测，这是由于存活率提高而非发病率的实际变化所致。或者，由于该登记册是根据卫生服务记录汇编而成的，对低体重儿随访改善导致的诊断获取偏倚可能导致患病率明显上升。

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