重新审视开放阅读框的定义。

The Definition of Open Reading Frame Revisited.

机构信息

Department of Bioinformatics, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany.

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.

出版信息

Trends Genet. 2018 Mar;34(3):167-170. doi: 10.1016/j.tig.2017.12.009. Epub 2018 Jan 30.

DOI:10.1016/j.tig.2017.12.009

PMID:29366605

Abstract

The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.

摘要

开放阅读框（ORF）这个术语对基因发现至关重要。令人惊讶的是，至少有三种定义在使用。我们讨论了几个分子生物学和生物信息学方面的问题，并建议使用 ORF 被终止密码子限定的定义。