Department of Bioinformatics, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, 07743 Jena, Germany.
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
Trends Genet. 2018 Mar;34(3):167-170. doi: 10.1016/j.tig.2017.12.009. Epub 2018 Jan 30.
The term open reading frame (ORF) is of central importance to gene finding. Surprisingly, at least three definitions are in use. We discuss several molecular biological and bioinformatics aspects, and we recommend using the definition in which an ORF is bounded by stop codons.
开放阅读框（ORF）这个术语对基因发现至关重要。令人惊讶的是，至少有三种定义在使用。我们讨论了几个分子生物学和生物信息学方面的问题，并建议使用 ORF 被终止密码子限定的定义。
