含BTB/POZ结构域蛋白7与涎腺腺样囊性癌中纤连蛋白的表达呈负相关。

BTB/POZ domain-containing protein 7 is inversely associated with fibronectin expression in salivary adenoid cystic carcinoma.

作者信息

Liu Yunxia, Song Jiwu, Zhang Jun, Yang Liu, Liu Zongxia, Wang Xuxia

机构信息

Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Shandong, China; Institute of Stomatology, Weifang Medical University, Weifang, Shandong, China; Department of Stomatology, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

Department of Stomatology, Weifang People's Hospital, Weifang, Shandong, China.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 May;125(5):468-477. doi: 10.1016/j.oooo.2017.12.004. Epub 2017 Dec 28.

DOI:10.1016/j.oooo.2017.12.004

PMID:29366608

Abstract

OBJECTIVE

This study aimed to investigate the relationship between BTB/POZ domain-containing protein 7 (BTBD7) and fibronectin (FN) expression in salivary adenoid cystic carcinoma (SACC) and the function of BTBD7 in proliferation, migration, and invasion of SACC cells.

STUDY DESIGN

The BTBD7 and FN expression in SACC and nontumor salivary tissues as well as SACC cells were characterized by immunohistochemistry and immunofluorescence. The effect of BTBD7 silencing on the proliferation, migration, and invasion of SACC-LM cells were determined by wound healing and transwell invasion assays.

RESULTS

The percentages of SACC with positive BTBD7 expression were significantly higher than those of SACC with FN expression. BTBD7 silencing significantly increased the relative levels of FN expression and inhibited the proliferation, migration, and invasion of SACC-LM cells.

CONCLUSIONS

The study data indicated that BTBD7 was inversely associated with FN expression in SACC. BTBD7 may inhibit FN expression, but it promotes the proliferation, migration, and invasion of SACC-LM cells. Hence, BTBD7 may be associated with metastasis and a new therapeutic target for intervention of SACC.

摘要