Levandowski R A, Ou D W, Jackson G G
J Infect Dis. 1986 Apr;153(4):743-8. doi: 10.1093/infdis/153.4.743.
Populations of peripheral blood leukocytes were enumerated in 15 volunteers challenged by intranasal inoculation with rhinovirus serotype 25. The results demonstrated a significant decrease in total lymphocyte count among infected persons on the third day after challenge with the virus (P less than .01). The change in lymphocyte count was associated with a significant decrease in total T cells, as determined by monoclonal antibodies (both T11+ and T3+, P less than .02), but not in B cells (B7+). Among the subsets of T cells, T4+ (T helper/inducer) and T8+ (T suppressor/cytotoxic) lymphocytes both declined in number, but only the change in the T4+ subset was significant. For each of the lymphocyte populations that decreased significantly (T3+, T11+, and T4+) there was a strong correlation with increased severity of symptoms. Persons who had the greatest decrease in total lymphocyte count also shed virus most frequently. The number of nonlymphocyte leukocytes increased with the severity of the symptoms. These data show that T lymphocytes (particularly the T4+ population) are related to both the progression of infection and the symptoms of the rhinovirus common cold.
对15名经鼻接种25型鼻病毒的志愿者的外周血白细胞群体进行了计数。结果显示，在病毒攻击后第三天，感染者的总淋巴细胞计数显著下降（P小于0.01）。淋巴细胞计数的变化与总T细胞的显著减少有关，这是通过单克隆抗体测定的（T11 +和T3 +均为P小于0.02），但B细胞（B7 +）没有减少。在T细胞亚群中，T4 +（辅助/诱导性T细胞）和T8 +（抑制/细胞毒性T细胞）淋巴细胞数量均下降，但只有T4 +亚群的变化具有统计学意义。对于显著减少的每个淋巴细胞群体（T3 +、T11 +和T4 +），其与症状严重程度增加密切相关。总淋巴细胞计数下降最多的人病毒排出也最频繁。非淋巴细胞白细胞的数量随着症状的严重程度而增加。这些数据表明，T淋巴细胞（特别是T4 +群体）与鼻病毒普通感冒的感染进展和症状均有关。
