瘦青春期多囊卵巢综合征患者血清鸢尾素浓度。

Serum irisin concentrations in lean adolescents with polycystic ovary syndrome.

机构信息

Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.

Unit of Clinical and Translational Research in Endocrinology, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.

出版信息

Clin Endocrinol (Oxf). 2018 Apr;88(4):585-591. doi: 10.1111/cen.13555. Epub 2018 Feb 12.

DOI:10.1111/cen.13555

PMID:29368340

Abstract

OBJECTIVE

To explore differences in irisin concentrations between lean adolescents with PCOS and age- and body mass index (BMI)-matched controls and examine the associations of irisin with core features of the syndrome.

DESIGN

Cross-sectional study.

PATIENTS

Lean females with PCOS, aged 13-21 years.

MEASUREMENTS

Physical, hormonal and sonographic assessment. Irisin concentrations were measured with ELISA.

RESULTS

Participants included in total 39 sedentary females (mean ± SD; age 17.3 ± 2.1 years, BMI 20.7 ± 1.3 Kg/m ), 23 adolescents with PCOS and 16 controls. Adolescents with PCOS compared to controls had significantly elevated concentrations of fasting serum irisin (mean ± SD; PCOS, 1.7 ± 1.0 μg/mL vs controls, 1.0 ± 0.4 μg/mL; P = .007), luteinizing hormone (LH), oestradiol, testosterone, Δ4-androstenedione, 17-hydroxyprogesterone, glucose, as well as free androgen index, Ferriman-Gallwey score and mean ovarian volume (MOV). For the total sample, circulating irisin was positively correlated with MOV (r = .332, P = .041), glucose (r = .428, P = .007), insulin (r = .369, P = .021) and HOMA-IR (r = .422, P = .007) and negatively correlated with QUICKI (r = -.329, P = .041). Follicle-stimulating hormone (B = 0.295, Beta = .342, P = .042) and MOV (B = 0.182, Beta = 0.821, P = .001) were positive predictors, and LH (B = -0.108, Beta = -0.523, P = .010) and testosterone (B = -0.431, Beta = -0.457, P = .032) were negative predictors of irisin concentrations, whereas irisin positively predicted fasting glucose (B = 0.262, Beta = 0.428, P = .007). In the PCOS group, irisin concentrations were positively correlated with HOMA-IR (r = .416, P = .048) but negatively correlated with LH (r = -.499, P = .015), testosterone (r = -.585, P = .003), free androgen index (r = -.426, P = .048) and Ferriman-Gallwey score (r = -.533, P = .015).

CONCLUSIONS

Irisin was associated with the adolescents' metabolic and reproductive characteristics and the hyperandrogenic phenotype of the syndrome. Much research is needed to ascertain mechanisms of elevated serum irisin in adolescent PCOS.

摘要

目的

探讨多囊卵巢综合征（PCOS）青少年瘦体与年龄和体重指数（BMI）匹配对照组之间鸢尾素浓度的差异，并研究鸢尾素与该综合征核心特征的相关性。

设计

横断面研究。

患者

13-21 岁的久坐不动的女性瘦体 PCOS 患者。

测量方法

进行体格、激素和超声评估。采用 ELISA 法检测鸢尾素浓度。

结果

共纳入 39 名久坐不动的女性（平均±标准差；年龄 17.3±2.1 岁，BMI 20.7±1.3kg/m²）、23 名 PCOS 青少年和 16 名对照者。与对照组相比，PCOS 青少年的空腹血清鸢尾素浓度明显升高（均值±标准差；PCOS，1.7±1.0μg/mL vs 对照组，1.0±0.4μg/mL；P=0.007）、黄体生成素（LH）、雌二醇、睾酮、Δ4-雄烯二酮、17-羟孕酮、血糖，以及游离雄激素指数、Ferriman-Gallwey 评分和平均卵巢体积（MOV）。对于总样本，循环鸢尾素与 MOV（r=0.332，P=0.041）、血糖（r=0.428，P=0.007）、胰岛素（r=0.369，P=0.021）和 HOMA-IR（r=0.422，P=0.007）呈正相关，与 QUICKI（r=-0.329，P=0.041）呈负相关。促卵泡激素（B=0.295，β=0.342，P=0.042）和 MOV（B=0.182，β=0.821，P=0.001）为阳性预测因子，而 LH（B=-0.108，β=-0.523，P=0.010）和睾酮（B=-0.431，β=-0.457，P=0.032）为阴性预测因子，而鸢尾素浓度与空腹血糖呈正相关（B=0.262，β=0.428，P=0.007）。在 PCOS 组中，鸢尾素浓度与 HOMA-IR（r=0.416，P=0.048）呈正相关，但与 LH（r=-0.499，P=0.015）、睾酮（r=-0.585，P=0.003）、游离雄激素指数（r=-0.426，P=0.048）和 Ferriman-Gallwey 评分（r=-0.533，P=0.015）呈负相关。