Adenis Antoine, Dufit Valentin, Douine Maylis, Ponty Jerome, Bianco Laure, Najioullah Fatiha, Kilié Odile, Catherine Dominique, Thomas Nadia, Deshayes Jean Luc, Brousse Paul, Carles Gabriel, Grenier Claire, Lacoste Vincent, Molinie Vincent, Cesaire Raymond, Nacher Mathieu
Centre d'Investigation Clinique Antilles-Guyane, CIC INSERM 1424, Centre hospitalier de Cayenne, Ave des Flamboyants, 97300, Cayenne, French Guiana.
Laboratoire de Virologie, CHU de la Martinique, Fort de France, Martinique.
BMC Womens Health. 2018 Jan 24;18(1):25. doi: 10.1186/s12905-017-0493-9.
Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana.
A study was conducted in women aged 20-65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups.
None of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3-11.2), P < 0.001.
It was not possible to predict which HPV-infected women will have cytological abnormalities or notfrom anamnesis. In this study HPV 53 seemed more benign than other HPV genotypes. On the contrary, species n°9, containing 5 of the genotypes contained in the nonavalent HPV vaccine, was significantly associated with more cytological abnormalities. HPV testing and vaccination with the nonavalent vaccine should be implemented in these remote parts of French Guiana.
使用宫颈细胞学检查进行宫颈癌预防的敏感性不足，相当一部分感染人乳头瘤病毒（HPV）的女性细胞学检查结果正常。本研究的目的是试图确定法属圭亚那偏远地区感染HPV的女性中与细胞学异常相关的因素。
对年龄在20 - 65岁、使用格瑞纳生物公司试剂盒通过HPV DNA检测确诊感染HPV的女性进行了一项研究。除了HPV检测外，还进行了细胞学检查，并将其分类为正常或异常。比较了正常和异常细胞学检查组之间的人口统计学和生活史变量以及感染基因型。
人口统计学和生活史变量均与细胞学检查结果无关。HPV基因型53与无细胞学异常显著相关，而HPV 52、58、16以及可能的33和66与细胞学异常风险增加独立相关。当将HPV基因型按不同种类分组时，只有种类9（HPV 16、31、33、35、52、58、67）与异常细胞学显著相关，比值比（AOR）= 5.1（95%置信区间[CI] = 2.3 - 11.2），P < 0.001。
无法通过既往史预测哪些感染HPV的女性会出现细胞学异常。在本研究中，HPV 53似乎比其他HPV基因型更具良性。相反，包含九价HPV疫苗中5种基因型的种类9与更多的细胞学异常显著相关。在法属圭亚那的这些偏远地区应开展HPV检测和九价疫苗接种。
