壳聚糖的化学修饰用于高效疫苗传递。
Chemical Modification of Chitosan for Efficient Vaccine Delivery.
机构信息
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Molecules. 2018 Jan 25;23(2):229. doi: 10.3390/molecules23020229.
Chitosan, which exhibits good biocompatibility, safety, microbial degradation and other excellent performances, has found application in all walks of life. In the field of medicine, usage of chitosan for the delivery of vaccine is favored by a wide range of researchers. However, due to its own natural limitations, its application has been constrained to the beginning of study. In order to improve the applicability for vaccine delivery, researchers have carried out various chemical modifications of chitosan. This review summarizes a variety of modification methods and applications of chitosan and its derivatives in the field of vaccine delivery.
壳聚糖具有良好的生物相容性、安全性、微生物降解性等优异性能，已广泛应用于各个领域。在医学领域，壳聚糖作为疫苗传递载体受到了广泛研究人员的青睐。然而，由于其自身的天然局限性，其应用一直局限于研究初期。为了提高其在疫苗传递方面的适用性，研究人员对壳聚糖进行了各种化学修饰。本文综述了壳聚糖及其衍生物在疫苗传递领域的各种修饰方法及应用。
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