Begum Rukaiah Fatma, Singh Sudarshan, Prajapati Bhupendra, Sumithra M, Patel Ravish J
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu, Tamil Nadu, India.
Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.
Curr Med Chem. 2025;32(19):3759-3789. doi: 10.2174/0109298673285334240112104709.
Cancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation or specific chemicals, and a family history of the disease. Common treatment methods for cancer encompass surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. These treatments aim to eliminate cancer cells while minimizing harm to healthy cells. Recent research has extensively explored the potential of bioactive compounds as agents for combating cancer. However, effectively delivering such compounds to specific target sites is a complex undertaking. Consequently, there has been widespread exploration of polymer applications in the development of nanomedicine for delivering bioactive substances. Additionally, the technique of grafting native excipients onto polymers has been investigated to enhance their versatility in the delivery of these compounds to specific tumor cells. This review offers a brief yet informative summary of how grafted chitosan is employed as a delivery system for bioactive phytopharmaceuticals possessing anticancer properties. In essence, it delves into the use of grafted chitosan in facilitating the transport and targeted release of these natural compounds that have demonstrated potential in combating cancer. This innovative approach has the potential to enhance the effectiveness of anticancer treatments and minimize their adverse effects on healthy cells.
癌症的特征是体内异常细胞不受控制地增殖和扩散，导致肿瘤或不规则细胞团的形成。导致癌症的因素错综复杂，涉及遗传、环境和生活方式等多种因素。癌症的风险因素包括使用尼古丁、过量饮酒、接触辐射或特定化学物质以及家族病史。癌症的常见治疗方法包括手术、放射治疗、化疗、免疫疗法和靶向治疗。这些治疗旨在消除癌细胞，同时将对健康细胞的损害降至最低。最近的研究广泛探索了生物活性化合物作为抗癌剂的潜力。然而，将这些化合物有效地输送到特定靶点是一项复杂的任务。因此，人们广泛探索了聚合物在开发用于输送生物活性物质的纳米医学中的应用。此外，还研究了将天然辅料接枝到聚合物上的技术，以提高它们将这些化合物输送到特定肿瘤细胞的通用性。本综述简要介绍了接枝壳聚糖如何用作具有抗癌特性的生物活性植物药的递送系统。实质上，它深入探讨了接枝壳聚糖在促进这些已显示出抗癌潜力的天然化合物的运输和靶向释放方面的应用。这种创新方法有可能提高抗癌治疗的有效性，并将其对健康细胞的副作用降至最低。
