Pastorello Ricardo Garcia, D'Almeida Costa Felipe, Osório Cynthia A B T, Makdissi Fabiana B A, Bezerra Stephania Martins, de Brot Marina, Campos Antonio Hugo J F M, Soares Fernando Augusto, Vassallo José
Department of Anatomic Pathology, A.C. Camargo Cancer Center, 211 Professor Antônio Prudente Street, Sao Paulo, Zip code 01509-900, Brazil.
Department of Breast Surgery, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
Diagn Pathol. 2018 Jan 25;13(1):10. doi: 10.1186/s13000-018-0688-x.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been published on this entity in recent years, a great number of patients and health professionals remain unaware of this diagnosis.
We herein report the case of a 56-year-old female with Li-FRAUMENI syndrome who presented with late right-sided recurrent breast swelling after prophylactic adenomastectomy with implant reconstruction. Imaging scans revealed an heterogeneous mass adjacent to the implant fibrous capsule. A biopsy of the lesion rendered the diagnosis of a BIA-ALCL.
This case presents similarities with previous reports, but also some particularities, which should be stressed in order to make the diagnosis the earliest possible. The most distinct feature is that this is the second report of BIA-ALCL arising in the setting of Li-FRAUMENI syndrome.
乳房植入物相关间变性大细胞淋巴瘤（BIA-ALCL）是一种罕见的恶性肿瘤，最近被世界卫生组织确认为一个暂定实体。尽管近年来关于该实体的报道越来越多，但仍有大量患者和卫生专业人员对这一诊断并不知晓。
我们在此报告一例56岁患有李-弗劳梅尼综合征的女性患者，该患者在预防性乳房切除术后进行植入物重建，出现右侧乳房晚期复发性肿胀。影像学扫描显示在植入物纤维囊附近有一个不均匀的肿块。对病变进行活检后诊断为BIA-ALCL。
该病例与之前的报道有相似之处，但也有一些特殊性，为尽早做出诊断应予以强调。最显著的特征是，这是第二例在李-弗劳梅尼综合征背景下发生的BIA-ALCL报告。
