色谱树脂在生物制药生产过程中的寿命和老化。
Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture.
机构信息
Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK.
Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India.
出版信息
Trends Biotechnol. 2018 Oct;36(10):992-995. doi: 10.1016/j.tibtech.2018.01.001. Epub 2018 Jan 20.
Abstract
Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.
摘要
对导致色谱柱老化的事件缺乏了解，使得难以监测柱的寿命。在这一领域缺乏既定的程序，使得难以建立行业标准。因此，了解树脂老化机制和监测操作过程中柱老化的技术非常重要。
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