Desai Jigar V
Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
J Fungi (Basel). 2018 Jan 11;4(1):10. doi: 10.3390/jof4010010.
is a commensal resident of the human gastrointestinal and genital tracts. Under conditions such as dysbiosis, host immune perturbances, or the presence of catheters/implanted medical devices, the fungus may cause debilitating mucosal or fatal systemic infections. The ability of to grow as long filamentous hyphae is critical for its pathogenic potential as it allows the fungus to invade the underlying substratum. In this brief review, I will outline the current understanding regarding the mechanistic regulation of hyphal growth and invasion in .
是人类胃肠道和生殖道的共生菌。在诸如生态失调、宿主免疫紊乱或存在导管/植入式医疗设备等情况下，这种真菌可能会导致使人衰弱的黏膜感染或致命的全身感染。它能够生长为长丝状菌丝，这对于其致病潜力至关重要，因为这使真菌能够侵入下层基质。在这篇简短的综述中，我将概述目前对其菌丝生长和侵入的机制调控的理解。
