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来自陆地和海洋栖息地的子囊菌产生的聚酮类红色素的生产及新提取方法

Production and New Extraction Method of Polyketide Red Pigments Produced by Ascomycetous Fungi from Terrestrial and Marine Habitats.

作者信息

Lebeau Juliana, Venkatachalam Mekala, Fouillaud Mireille, Petit Thomas, Vinale Francesco, Dufossé Laurent, Caro Yanis

机构信息

Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de la Réunion, F-97490 Sainte-Clotilde, Ile de la Réunion, France.

UMR QualiSud, Université de la Réunion, IUT, F-97410 Saint-Pierre, Ile de la Réunion, France.

出版信息

J Fungi (Basel). 2017 Jun 28;3(3):34. doi: 10.3390/jof3030034.

DOI:10.3390/jof3030034
PMID:29371552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5715940/
Abstract

The use of ascomycetous fungi as pigment producers opens the way to an alternative to synthetic dyes, especially in the red-dye industries, which have very few natural pigment alternatives. The present paper aimed to bio-prospect and screen out 15 selected ascomycetous fungal strains, originating from terrestrial and marine habitats belonging to seven different genera (, , , , , , and ). We identified four strains, , , marine strains identified as spp., and , as potential red pigment producers. The extraction of the pigments is a crucial step, whereby the qualitative and quantitative compositions of each fungal extract need to be respected for reliable identification, as well as preserving bioactivity. Furthermore, there is a growing demand for more sustainable and cost-effective extraction methods. Therefore, a pressurized liquid extraction technique was carried out in this study, allowing a greener and faster extraction step of the pigments, while preserving their chemical structures and bioactivities in comparison to conventional extraction processes. The protocol was illustrated with the production of pigment extracts from and spp. Extracts were analyzed by high-performance liquid-chromatography combined with photodiode array-detection (HPLC-DAD) and high-resolution mass spectrometry (UHPLC-HRMS). The more promising strain was the isolate spp. of marine origin. The main polyketide pigment produced by this strain has been characterized as -threoninerubropunctamine, a non-toxic red -like azaphilone pigment.

摘要

将子囊菌用作色素生产者为合成染料提供了一种替代品，特别是在红色染料行业，该行业几乎没有天然色素替代品。本文旨在对来自陆地和海洋栖息地、属于七个不同属（、、、、、、和）的15种选定子囊菌菌株进行生物勘探和筛选。我们鉴定出四种菌株，、、被鉴定为 spp. 的海洋菌株以及，作为潜在的红色色素生产者。色素的提取是关键步骤，为了可靠鉴定以及保留生物活性，每种真菌提取物的定性和定量组成都需要得到重视。此外，对更可持续且具成本效益的提取方法的需求日益增长。因此，本研究采用了加压液体萃取技术，与传统提取工艺相比，该技术能更绿色、快速地提取色素，同时保留其化学结构和生物活性。该方案通过从和 spp. 生产色素提取物进行了说明。提取物通过高效液相色谱结合光电二极管阵列检测（HPLC-DAD）和高分辨率质谱（UHPLC-HRMS）进行分析。最有前景的菌株是海洋来源的分离株 spp.。该菌株产生的主要聚酮类色素已被鉴定为 - 苏氨酸红刺孢胺，一种无毒的红色类氮杂环庚三烯酮色素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/c567d1d1407b/jof-03-00034-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/7365c750490a/jof-03-00034-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/2b22b68017eb/jof-03-00034-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/c98b3da776a2/jof-03-00034-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/2bd81113d599/jof-03-00034-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/1e5b0083cb2e/jof-03-00034-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/f84405c164c7/jof-03-00034-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/c567d1d1407b/jof-03-00034-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/7365c750490a/jof-03-00034-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/2b22b68017eb/jof-03-00034-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/c98b3da776a2/jof-03-00034-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/2bd81113d599/jof-03-00034-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/1e5b0083cb2e/jof-03-00034-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/f84405c164c7/jof-03-00034-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/162a/5715940/c567d1d1407b/jof-03-00034-g007.jpg

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