正念疗法或常规治疗对抑郁、焦虑、压力和适应障碍患者的巨噬细胞移动抑制因子和 microRNA-451a 的影响。
Macrophage Migration Inhibitory Factor and microRNA-451a in Response to Mindfulness-based Therapy or Treatment as Usual in Patients with Depression, Anxiety, or Stress and Adjustment Disorders.
机构信息
Center for Primary Health Care Research, Lund University/Region Skåne, Sweden.
出版信息
Int J Neuropsychopharmacol. 2018 Jun 1;21(6):513-521. doi: 10.1093/ijnp/pyy001.
BACKGROUND
Macrophage migration inhibitory factor is a proinflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a can directly target macrophage migration inhibitory factor and downregulate its expression in cells. However, the role of macrophage migration inhibitory factor and microRNA-451a in psychiatric patients treated with psychotherapeutic interventions is unknown. In this study, our aim was to investigate levels of macrophage migration inhibitory factor and its regulating microRNA-451a in patients with depression, anxiety, or stress and adjustment disorders who underwent mindfulness-based therapy or treatment as usual.
METHODS
A total of 168 patients with psychiatric disorders were included from a randomized controlled trial that compared mindfulness-based therapy with treatment as usual. Plasma levels of macrophage migration inhibitory factor and microRNA-451a were measured at baseline and after the 8-week follow-up using Luminex assay and qPCR.
RESULTS
Macrophage migration inhibitory factor levels decreased significantly in patients posttreatment, whereas microRNA-451a levels showed a nonsignificant change. Macrophage migration inhibitory factor levels were inversely associated with microRNA-451a expression levels at baseline (β=-0.04, P=.008). The change in macrophage migration inhibitory factor levels (follow-up levels minus baseline levels) was associated with the change in microRNA-451a (follow-up levels minus baseline levels) (β=-0.06, P < .0001). The change in either macrophage migration inhibitory factor or microRNA-451a was not associated with improvement in psychiatric symptoms.
CONCLUSION
We demonstrate that the levels of macrophage migration inhibitory factor decreased after psychotherapeutic interventions in patients with psychiatric disorders. However, this reduction was not associated with an improvement in psychiatric symptoms in response to the treatment. We also found an association between macrophage migration inhibitory factor and its regulating microRNA. However, this association needs to be further examined in future studies.
背景
巨噬细胞移动抑制因子是一种促炎细胞因子，与各种精神疾病有关。microRNA-451a 可以直接靶向巨噬细胞移动抑制因子并下调细胞中的表达。然而，在接受心理治疗干预的精神科患者中，巨噬细胞移动抑制因子和 microRNA-451a 的作用尚不清楚。在这项研究中，我们的目的是研究抑郁症、焦虑症或应激和适应障碍患者在接受正念为基础的治疗或常规治疗后，巨噬细胞移动抑制因子及其调节 microRNA-451a 的水平。
方法
从一项比较正念为基础的治疗与常规治疗的随机对照试验中纳入了 168 例精神科患者。使用 Luminex assay 和 qPCR 在基线和 8 周随访时测量巨噬细胞移动抑制因子和 microRNA-451a 的血浆水平。
结果
治疗后患者的巨噬细胞移动抑制因子水平显著下降，而 microRNA-451a 水平变化不显著。巨噬细胞移动抑制因子水平与基线时的 microRNA-451a 表达水平呈负相关（β=-0.04，P=.008）。巨噬细胞移动抑制因子水平的变化（随访水平减去基线水平）与 microRNA-451a 的变化（随访水平减去基线水平）相关（β=-0.06，P<0.0001）。巨噬细胞移动抑制因子或 microRNA-451a 的变化与精神症状的改善无关。
结论
我们证明了在精神障碍患者接受心理治疗干预后，巨噬细胞移动抑制因子的水平降低。然而，这种降低与治疗后精神症状的改善无关。我们还发现了巨噬细胞移动抑制因子与其调节的 microRNA 之间的关联。然而，这种关联需要在未来的研究中进一步研究。
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