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一名 17 岁男性,右侧面瘫,左侧下肢无力,颅骨溶骨性病变。

A 17-Year-Old Boy With Right Face Palsy, Left Leg Weakness, and Lytic Skull-Bone Lesions.

机构信息

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

出版信息

J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):350-354. doi: 10.1093/jpids/pix101.

Abstract

Human T-cell lymphotropic virus (HTLV), an infection that is endemic in certain parts of Asia, Africa, and South America, has been associated with malignancy and neurological deficits. Here, we describe a pediatric patient with chronic HTLV-I infection who developed complications associated with HTLV-I (ie, adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis). To our knowledge, this presentation in a child has never been described. The patient underwent a bone marrow transplant and, at the time of this writing, was in remission. This case report highlights the fact that HTLV-related complications, previously expected to occur after decades of infection, also can occur in pediatric patients, particularly those who acquired HTLV-I perinatally.

摘要

人类 T 细胞嗜淋巴细胞病毒(HTLV)在亚洲、非洲和南美洲的某些地区流行,与恶性肿瘤和神经功能缺损有关。在这里,我们描述了一例患有慢性 HTLV-I 感染的儿科患者,该患者出现了与 HTLV-I 相关的并发症(即成人 T 细胞白血病/淋巴瘤和 HTLV-I 相关脊髓病/热带痉挛性截瘫)。据我们所知,这种在儿童中的表现以前从未被描述过。该患者接受了骨髓移植,在撰写本文时,处于缓解期。本病例报告强调了这样一个事实,即以前认为在感染数十年后才会发生的与 HTLV 相关的并发症,也可能发生在儿科患者中,尤其是那些围产期感染 HTLV-I 的患者。

相似文献

2
Human T-cell leukemia virus (HTLV)-associated neuropathy.人类T细胞白血病病毒(HTLV)相关神经病
Handb Clin Neurol. 2013;115:531-41. doi: 10.1016/B978-0-444-52902-2.00030-8.

本文引用的文献

6
Epidemiological Aspects and World Distribution of HTLV-1 Infection.HTLV-1 感染的流行病学特征和世界分布。
Front Microbiol. 2012 Nov 15;3:388. doi: 10.3389/fmicb.2012.00388. eCollection 2012.

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