Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):350-354. doi: 10.1093/jpids/pix101.
Human T-cell lymphotropic virus (HTLV), an infection that is endemic in certain parts of Asia, Africa, and South America, has been associated with malignancy and neurological deficits. Here, we describe a pediatric patient with chronic HTLV-I infection who developed complications associated with HTLV-I (ie, adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis). To our knowledge, this presentation in a child has never been described. The patient underwent a bone marrow transplant and, at the time of this writing, was in remission. This case report highlights the fact that HTLV-related complications, previously expected to occur after decades of infection, also can occur in pediatric patients, particularly those who acquired HTLV-I perinatally.
人类 T 细胞嗜淋巴细胞病毒(HTLV)在亚洲、非洲和南美洲的某些地区流行,与恶性肿瘤和神经功能缺损有关。在这里,我们描述了一例患有慢性 HTLV-I 感染的儿科患者,该患者出现了与 HTLV-I 相关的并发症(即成人 T 细胞白血病/淋巴瘤和 HTLV-I 相关脊髓病/热带痉挛性截瘫)。据我们所知,这种在儿童中的表现以前从未被描述过。该患者接受了骨髓移植,在撰写本文时,处于缓解期。本病例报告强调了这样一个事实,即以前认为在感染数十年后才会发生的与 HTLV 相关的并发症,也可能发生在儿科患者中,尤其是那些围产期感染 HTLV-I 的患者。