人类杂合性：一种新的估计。
Human heterozygosity: a new estimate.
作者信息
McConkey E H, Taylor B J, Phan D
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6500-4. doi: 10.1073/pnas.76.12.6500.
Abstract
Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.
摘要
在能够区分仅因一个带电荷氨基酸不同的等位基因产物的条件下，通过高分辨率二维聚丙烯酰胺凝胶电泳和双标记放射自显影技术，对来自四个人二倍体成纤维细胞系的数百种多肽进行了比较。对于涉及带电荷氨基酸的变化，这组基因产物所代表的平均杂合度似乎小于1%。
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