Department of Neurobiology,
Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, Maryland 21250.
J Neurosci. 2018 Feb 14;38(7):1601-1607. doi: 10.1523/JNEUROSCI.0508-17.2018. Epub 2018 Jan 26.
With ever-increasing advancements in technology, neuroscientists are able to collect data in greater volumes and with finer resolution. The bottleneck in understanding how the brain works is consequently shifting away from the amount and type of data we can collect and toward what we actually do with the data. There has been a growing interest in leveraging this vast volume of data across levels of analysis, measurement techniques, and experimental paradigms to gain more insight into brain function. Such efforts are visible at an international scale, with the emergence of big data neuroscience initiatives, such as the BRAIN initiative (Bargmann et al., 2014), the Human Brain Project, the Human Connectome Project, and the National Institute of Mental Health's Research Domain Criteria initiative. With these large-scale projects, much thought has been given to data-sharing across groups (Poldrack and Gorgolewski, 2014; Sejnowski et al., 2014); however, even with such data-sharing initiatives, funding mechanisms, and infrastructure, there still exists the challenge of how to cohesively integrate all the data. At multiple stages and levels of neuroscience investigation, machine learning holds great promise as an addition to the arsenal of analysis tools for discovering how the brain works.
随着技术的不断进步,神经科学家能够以更高的分辨率收集更多的数据。因此,理解大脑如何工作的瓶颈正逐渐从我们可以收集的数据的数量和类型转移到我们实际上如何处理这些数据。人们越来越感兴趣的是利用这些庞大的数据集,跨越分析、测量技术和实验范例的各个层次,以更深入地了解大脑功能。这种努力在国际范围内可见一斑,出现了大数据神经科学计划,如大脑倡议(Bargmann 等人,2014 年)、人类大脑计划、人类连接组计划和国家心理健康研究所的研究领域标准倡议。在这些大型项目中,人们已经考虑了在各个小组之间共享数据(Poldrack 和 Gorgolewski,2014 年;Sejnowski 等人,2014 年);然而,即使有这样的数据共享计划、资金机制和基础设施,仍然存在如何将所有数据整合在一起的挑战。在神经科学研究的多个阶段和层次上,机器学习作为发现大脑工作方式的分析工具库的补充,具有很大的潜力。