Al-Rifai Rami H, Ali Nasloon, Barigye Esther T, Al Haddad Amal H I, Loney Tom, Al-Maskari Fatima, Ahmed Luai A
College of Medicine and Health Sciences, Institute of Public Health, United Arab Emirates University, Al Ain, United Arab Emirates.
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
BMJ Open. 2018 Jan 27;8(1):e019843. doi: 10.1136/bmjopen-2017-019843.
Cohort studies have revealed that genetic, socioeconomic, communicable and non-communicable diseases, and environmental exposures during pregnancy may influence the mother and her pregnancy, birth delivery and her offspring. Numerous studies have been conducted in the Gulf Cooperation Council (GCC) countries to examine maternal and birth health. The objectives of this protocol for a systematic review are to systematically review and characterise the exposures and outcomes that have been examined in the mother and birth cohort studies in the GCC region, and to summarise the strength of association between key maternal exposures during pregnancy (ie, body mass index) and different health-related outcomes (ie, mode of birth delivery). The review will then synthesise and characterise the consequent health implications and will serve as a platform to help identify areas that are overlooked, point out limitations of studies and provide recommendations for future cohort studies.
Medline, Embase, Cochrane Library and Web of Science electronic databases will be comprehensively searched. Two reviewers will independently screen each study for eligibility, and where discrepancies arise they will be discussed and resolved; otherwise a third reviewer will be consulted. The two reviewers will also independently extract data into a predefined Excel spreadsheet. The included studies will be categorised on the basis of whether the participant is a mother, infant or mother-infant dyad. Outcome variables will be divided along two distinctions: mother or infant. Exposure variables will be divided into six domains: psychosocial, biological, environmental, medical/medical services, maternal/reproductive and perinatal/child. Studies are expected to be of heterogeneous nature; therefore, quantitative syntheses might be limited.
There is no primary data collection; therefore, ethical review is not necessary. The findings of this review will be disseminated in a peer-reviewed journal and presented at relevant conferences.
CRD42017068910.
队列研究表明，遗传因素、社会经济状况、传染病和非传染病以及孕期的环境暴露可能会影响母亲及其妊娠、分娩和后代。海湾合作委员会（GCC）国家已经开展了大量研究来调查孕产妇和出生健康情况。本系统评价方案的目的是系统评价和描述海湾合作委员会地区母亲和出生队列研究中所考察的暴露因素和结局，并总结孕期关键孕产妇暴露因素（即体重指数）与不同健康相关结局（即分娩方式）之间的关联强度。该评价随后将综合并描述由此产生的健康影响，并将作为一个平台，以帮助识别被忽视的领域，指出研究的局限性，并为未来的队列研究提供建议。
将全面检索Medline、Embase、Cochrane图书馆和科学引文索引电子数据库。两名评审员将独立筛选每项研究的合格性，如有分歧将进行讨论并解决；否则将咨询第三位评审员。两名评审员还将独立将数据提取到预定义的Excel电子表格中。纳入的研究将根据参与者是母亲、婴儿还是母婴二元组进行分类。结局变量将分为两类：母亲或婴儿。暴露变量将分为六个领域：心理社会、生物学、环境、医疗/医疗服务、孕产妇/生殖和围产期/儿童。预计研究性质各异；因此，定量综合分析可能会受到限制。
无需收集原始数据；因此，无需进行伦理审查。本评价的结果将在同行评审期刊上发表，并在相关会议上展示。
PROSPERO注册号：CRD42017068910。
