Gera Ritika, Mokbel Ramia, Igor Ivanna, Mokbel Kefah
The London Breast Institute, Princess Grace Hospital, HCA Healthcare, London, U.K.
University College London Medical School, London, U.K.
Anticancer Res. 2018 Feb;38(2):707-716. doi: 10.21873/anticanres.12276.
BACKGROUND/AIM: Hair dye may contain mutagenic compounds which could be associated with an increased incidence of breast cancer in women who use it. The aim of this study was to examine the association between the personal use of hair dyes and the risk of breast cancer.
We conducted a literature review of epidemiological studies reporting breast cancer-specific risks among hair dye users versus non-users. The data for the incidence of breast cancer following the 'ever' use of hair dye in studies which met the inclusion criteria was analysed using a meta-analysis. The relative risk ratio (RR) and 95% confidence intervals (CI) were determined.
A total of eight case-control studies published between 1980 and 2017 met the selection criteria and were included in the meta-analysis. Compared to non-users, using a random effects model and the Duval and Tweedie's trim and fill procedure to adjust for publication bias in the presence of between studies heterogeneity, the adjusted RR for women using hair dyes was 1.1885 (95% CI=1.03228-1.36835). This indicates an 18.8% increased risk of future development of breast cancer among hair dye users.
Although further work is required to confirm our results and clarify potential mechanisms, our findings suggest that exposure to hair dyes may contribute to an increased breast cancer risk.
背景/目的：染发剂可能含有致突变化合物，这可能与使用染发剂的女性患乳腺癌的几率增加有关。本研究的目的是调查个人使用染发剂与患乳腺癌风险之间的关联。
我们对报告染发剂使用者与非使用者之间乳腺癌特异性风险的流行病学研究进行了文献综述。使用荟萃分析对符合纳入标准的研究中“曾经”使用染发剂后乳腺癌发病率的数据进行了分析。确定了相对风险比（RR）和95%置信区间（CI）。
1980年至2017年间发表的共有八项病例对照研究符合选择标准，并纳入荟萃分析。与非使用者相比，在存在研究间异质性的情况下，使用随机效应模型以及Duval和Tweedie的修剪和填充程序来调整发表偏倚，使用染发剂的女性调整后的RR为1.1885（95%CI=1.03228-1.36835）。这表明染发剂使用者未来患乳腺癌的风险增加了18.8%。
尽管需要进一步的研究来证实我们的结果并阐明潜在机制，但我们的研究结果表明，接触染发剂可能会增加患乳腺癌的风险。
