Department of Intensive Care Medicine, The First Hospital of China Medical University, Liaoning, 110001, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Lipids Health Dis. 2018 Jan 29;17(1):18. doi: 10.1186/s12944-018-0666-z.
Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.
A two-sample MR approach was used to examine the causal effect of diet/lifestyle upon risk of T2DM and glycemic traits.
The protein intake-increasing allele C of FTO was significant associated with higher risk of T2DM (Beta ± SE = 0.104 ± 0.014, P = 4.40 × 10), higher level of HOMA-IR (Beta ± SE = 0.016 ± 0.004, P = 9.55 × 10), HOMA-B (Beta ± SE = 0.008 ± 0.003, P = 0.020). Using MR analyses, increased protein intake was causally associated with an increased risk of T2DM (Beta ± SE = 0.806 ± 0.260, P = 0.002). In addition, smoking cessation was causally associated with increased levels of glycemic traits such as HOMA-IR (Beta ± SE = 0.165 ± 0.072, P = 0.021), fasting insulin (Beta ± SE = 0.132 ± 0.066, P = 0.047) and fasting glucose (Beta ± SE = 0.132 ± 0.064, P = 0.039).
These results provide evidence supporting a causal role for higher protein intake and smoking cession in T2DM. Our study provides further rationale for individuals at risk for diabetes to keep healthy lifestyle.
观察性研究表明，饮食/生活方式在 2 型糖尿病（T2DM）的发展中起作用；然而，这些关系是否具有因果关系尚不清楚。
采用两样本 MR 方法研究饮食/生活方式对 T2DM 风险和血糖特征的因果影响。
FTO 基因的蛋白摄入量增加等位基因 C 与 T2DM 风险增加显著相关（Beta ± SE = 0.104 ± 0.014，P = 4.40 × 10-4），HOMA-IR 水平升高（Beta ± SE = 0.016 ± 0.004，P = 9.55 × 10-4），HOMA-B 水平升高（Beta ± SE = 0.008 ± 0.003，P = 0.020）。使用 MR 分析，增加蛋白质摄入与 T2DM 风险增加有因果关系（Beta ± SE = 0.806 ± 0.260，P = 0.002）。此外，戒烟与血糖特征水平升高有因果关系，如 HOMA-IR（Beta ± SE = 0.165 ± 0.072，P = 0.021）、空腹胰岛素（Beta ± SE = 0.132 ± 0.066，P = 0.047）和空腹血糖（Beta ± SE = 0.132 ± 0.064，P = 0.039）。
这些结果提供了证据支持更高的蛋白质摄入和戒烟与 T2DM 之间存在因果关系。我们的研究为有患糖尿病风险的个体提供了保持健康生活方式的进一步理由。
