使用新型施莱姆管微导管进行实验性环形巩膜静脉管成形术。
Experimental circumferential canaloplasty with a new Schlemm canal microcatheter.
作者信息
Xie Mao-Song, Zheng Yong-Zheng, Huang Li-Bin, Xu Guo-Xing
机构信息
Department of Ophthalmology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.
Department of Ophthalmology, Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350005, Fujian Province, China.
出版信息
Int J Ophthalmol. 2018 Jan 18;11(1):1-5. doi: 10.18240/ijo.2018.01.01. eCollection 2018.
AIM
To present a new, simple, inexpensive Schlemm canal microcatheter for circumferential canaloplasty in a rabbit model.
METHODS
A rabbit glaucoma animal model was established by intravitreal injection of triamcinolone acetonide. Circumferential canaloplasty with a new Schlemm canal microcatheter (patent license number: 201220029850.0) was performed. The Schlemm canal microcatheter was composed of microcatheter wall and lumen. The wall was made of high refractive index plastic optical fiber that could be attached to an illuminant so that the whole lighted microcatheter was visible during circumferential canaloplasty. The lumen could be attached to an injector for injection of viscoelastic during catheterization. Rabbits were divided randomly into the control, model and treatment groups. Intraocular pressure (IOP) was measured with a Tono-pen tonometer pre-operation and 3, 7, 14, 21 and 28d post-operation. Ultrasound biomicroscopy was performed to visualize the Schlemm canal microcatheter in the Schlemm canal and the sclera pool.
RESULTS
The Schlemm canal microcatheter could be used to perform circumferential canaloplasty in the rabbit glaucoma animal model. IOP was lower in the treatment group than that in the model group 3, 7, 14 and 28d after operation. There were no significant differences in IOP between the control group and treatment group. The differences among the three groups were statistically significant (3d: =41.985, <0.001; 7d: =65.696, <0.001; 14d: =114.599, <0.001; 28d: =55.006, <0.001).
CONCLUSION
Circumferential canaloplasty is safe and effective in control of experimental glaucoma model in rabbits.
目的
在兔模型中展示一种用于环形小梁网成形术的新型、简单且廉价的施莱姆管微导管。
方法
通过玻璃体内注射曲安奈德建立兔青光眼动物模型。使用新型施莱姆管微导管（专利许可证号：201220029850.0）进行环形小梁网成形术。施莱姆管微导管由微导管壁和管腔组成。管壁由高折射率塑料光纤制成，可连接到光源，以便在环形小梁网成形术期间整个发光的微导管可见。管腔可连接到注射器，以便在插管期间注入粘弹性物质。将兔子随机分为对照组、模型组和治疗组。术前及术后3、7、14、21和28天用Tono-pen眼压计测量眼压。进行超声生物显微镜检查以观察施莱姆管微导管在施莱姆管和巩膜池中的情况。
结果
施莱姆管微导管可用于兔青光眼动物模型的环形小梁网成形术。术后3、7、14和28天，治疗组的眼压低于模型组。对照组和治疗组之间的眼压无显著差异。三组之间的差异具有统计学意义（3天：=41.985，<0.001；7天：=65.696，<0.001；14天：=114.599，<0.001；28天：=55.006，<0.001）。
结论
环形小梁网成形术在控制兔实验性青光眼模型方面安全有效。
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