小胶质细胞在青光眼性神经退行性变进展中的作用——综述
The role of microglia in the progression of glaucomatous neurodegeneration- a review.
作者信息
Zeng Hui-Lan, Shi Jing-Ming
机构信息
Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
出版信息
Int J Ophthalmol. 2018 Jan 18;11(1):143-149. doi: 10.18240/ijo.2018.01.22. eCollection 2018.
Abstract
Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.
摘要
青光眼是全球不可逆性失明的主要严重病因。降低眼压并不总能阻止青光眼性神经变性，在眼压正常的情况下，视神经可能会继续受损。小胶质细胞活性在中枢神经系统（CNS）发病机制以及视网膜神经节细胞（RGC）存活中发挥着重要作用。青光眼神经变性与小胶质细胞之间的关系非常复杂，目前仍不清楚。在本综述中，我们总结了小胶质细胞在青光眼神经变性机制方面的最新研究，这可能为青光眼治疗提供新方法。
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