Zhang Hui-Xian, Ma Kun, Tong Ya-Jing
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2017 Dec;42(23):4464-4473. doi: 10.19540/j.cnki.cjcmm.20171012.006.
To systematically evaluate the efficacy and safety of Bushen Huoxue ricipe in treating patients suffering from diminished ovarian reserve. Databases such as CNKI, WanFang, VIP, CBM, PubMed, EMbase and Cochrane Library were searched on randomized controlled trial/quasi-randomized controlled trial about Bushen Huoxue ricipe in treating patients suffering from diminished ovarian reserve form the inception of the study until June 2017. The studies were screened according to inclusion and exclusion criteria. Risk of bias evaluation tools were adopted to conduct quality evaluation. Meta-analysis on outcome indicator was performed by RevMan Version 5.3 Software. Due to the different Bushen Huoxue recipe (observation group) and the different Western medicine(control group) of all included studies, the effect size was combined by the random effect model after the subgroup analysis or sensitivity analysis was performed. Eventually 11 trials were included, including 733 cases of patients. Results of Meta-analysis indicated that, Bushen Huoxue recipe had advantages over Western medicine on lowering FSH, increasing AMH and AFC, enhancing the Chinese medicine symptom curative effect; Bushen Huoxue recipe had no advantages over Western medicine on increasing E2; the advantages of Bushen Huoxue recipe were not clear on reducing FSH/LH and increasing total effective rate because of the different outcomes to compared with the different Western medicine; no serious adverse reaction appering from Bushen Huoxue recipe was reported in the including researches. Bushen Huoxue recipe has the clinical curative effect and high safety suffering from diminished ovarian reserve. However, limited by the poor quantity of studies, these conclusions remain to be examined by more center, more sample and high-quality studies.
系统评价补肾活血方治疗卵巢储备功能下降患者的疗效及安全性。检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、EMbase和Cochrane图书馆等数据库，收集从研究起始至2017年6月关于补肾活血方治疗卵巢储备功能下降的随机对照试验/半随机对照试验。根据纳入和排除标准筛选研究。采用偏倚风险评估工具进行质量评价。使用RevMan 5.3软件对结局指标进行Meta分析。由于纳入研究中补肾活血方（观察组）及西药（对照组）各不相同，经亚组分析或敏感性分析后，采用随机效应模型合并效应量。最终纳入11项试验，共733例患者。Meta分析结果显示，补肾活血方在降低促卵泡生成素（FSH）、提高抗苗勒管激素（AMH）及窦卵泡计数（AFC）、提高中医症状疗效方面优于西药；在提高雌二醇（E2）水平方面，补肾活血方与西药相当；由于与不同西药比较的结果不同，补肾活血方在降低FSH/LH及提高总有效率方面优势不明显；纳入研究中未报道补肾活血方有严重不良反应。补肾活血方治疗卵巢储备功能下降有临床疗效且安全性高。但受研究数量限制，这些结论仍有待更多中心、更大样本、高质量研究进一步验证。
