Fernando W M A D Binosha, Rainey-Smith Stephanie R, Gardener Samantha L, Villemagne Victor L, Burnham Samantha C, Macaulay S Lance, Brown Belinda M, Gupta Veer Bala, Sohrabi Hamid R, Weinborn Michael, Taddei Kevin, Laws Simon M, Goozee Kathryn, Ames David, Fowler Christopher, Maruff Paul, Masters Colin L, Salvado Olivier, Rowe Christopher C, Martins Ralph N
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
Sir James McCusker Alzheimer's Disease Research Unit, (Hollywood Private Hospital), Perth, WA, Australia.
J Alzheimers Dis. 2018;61(4):1589-1598. doi: 10.3233/JAD-170742.
Accumulating evidence suggests a diet high in protein and fiber may confer some protection against Alzheimer's disease (AD). However, no human studies to-date have assessed the relationship between protein and fiber intake, and plasma and brain amyloid-β (Aβ). Consequently, this cross-sectional study, investigated the association of self-reported dietary intakes of protein and fiber, with plasma and brain Aβ burden (n = 541, and n = 162 respectively), in a well-characterized cohort of cognitively normal older adults, drawn from the larger Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. We observed 12.59 and 8.43 higher odds of 'high' brain Aβ burden (PiB PET SUVR≥1.5) if protein intake fell in the lowest and middle tertile, respectively, compared to the highest tertile (p = 0.008; p = 0.013). Thus, in this cohort, the more protein consumed, the less likelihood of 'high' Aβ burden in the brain. No other significant associations were observed. The results of this study highlight the potentially protective impact of high dietary protein intake on brain Aβ burden in older adults, before objective memory decline is apparent. While longitudinal validation is required, these findings may assist in the development of dietary approaches aimed at preventing or delaying AD onset.
越来越多的证据表明，高蛋白和高纤维饮食可能对阿尔茨海默病（AD）有一定的预防作用。然而，迄今为止，尚无人体研究评估蛋白质和纤维摄入量与血浆及脑淀粉样蛋白-β（Aβ）之间的关系。因此，这项横断面研究在一个来自规模更大的澳大利亚衰老成像、生物标志物和生活方式（AIBL）研究的认知正常的老年人群队列中，调查了自我报告的蛋白质和纤维饮食摄入量与血浆及脑Aβ负荷（分别为n = 541和n = 162）之间的关联。我们观察到，如果蛋白质摄入量处于最低和中间三分位数，与最高三分位数相比，脑Aβ负荷“高”（PiB PET SUVR≥1.5）的几率分别高出12.59倍和8.43倍（p = 0.008；p = 0.013）。因此，在这个队列中，摄入的蛋白质越多，脑内Aβ负荷“高”的可能性就越小。未观察到其他显著关联。这项研究的结果突出了高膳食蛋白质摄入量对老年人脑Aβ负荷的潜在保护作用，此时客观记忆衰退尚不明显。虽然需要纵向验证，但这些发现可能有助于制定旨在预防或延缓AD发病的饮食方法。
