Hall James R, Wiechmann April, Johnson Leigh A, Edwards Melissa, O'Bryant Sid E
Center for Alzheimer's and Neurodegenerative Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
J Alzheimers Dis. 2018;61(4):1485-1492. doi: 10.3233/JAD-170836.
Subjective cognitive complaints in cognitively normal adults have been linked to later cognitive decline and dementia. Research on the characteristics of this group has been conducted on a variety of clinical and community-based populations. The current study focuses on the rapidly expanding population of Mexican-American elders.
The objective of the study is the determination of characteristics of cognitively normal Mexican-Americans with cognitive complaints.
Data on 319 cognitively normal participants in a large-scale community-based study of elderly Mexican-Americans (HABLE) were analyzed comparing those with cognitive complaints with those without on clinical characteristics, affective status, neuropsychological functioning, and proteomic markers.
Those expressing concern about cognitive decline scored lower on the MMSE, were more likely to have significantly more affective symptoms, higher levels of diabetic markers, poorer performance on attention and executive functioning, and a different pattern of inflammatory markers.
Although longitudinal research is needed to determine the impact of these differences on later cognition, possible targets for early intervention with Mexican-Americans were identified.
认知正常的成年人的主观认知主诉与后期认知能力下降和痴呆症有关。针对这一群体特征的研究已在各种临床和社区人群中展开。当前研究聚焦于迅速增长的墨西哥裔美国老年人。
本研究的目的是确定有认知主诉的认知正常的墨西哥裔美国人的特征。
在一项针对墨西哥裔美国老年人的大规模社区研究（HABLE）中，分析了319名认知正常参与者的数据，比较了有认知主诉者和无认知主诉者在临床特征、情感状态、神经心理功能和蛋白质组学标志物方面的差异。
表达对认知能力下降担忧的人在简易精神状态检查表（MMSE）上得分较低，更有可能有明显更多的情感症状、更高水平的糖尿病标志物、在注意力和执行功能方面表现较差，以及有不同模式的炎症标志物。
尽管需要进行纵向研究来确定这些差异对后期认知的影响，但已确定了对墨西哥裔美国人进行早期干预的可能目标。
