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慢性淋巴细胞白血病患者的皮肤原藻病:一例报告及文献复习

Cutaneous Protothecosis in a Patient with Chronic Lymphocytic Leukemia: A Case Report and Literature Review.

作者信息

Nguyen Quynh-Giao Ly, Rosen Ted

机构信息

Department of Dermatology, Baylor College of Medicine, 1977 Butler Blvd, Suite E6.200, Houston, TX 77030, USA.

出版信息

J Fungi (Basel). 2015 Jan 14;1(1):4-12. doi: 10.3390/jof1010004.

DOI:10.3390/jof1010004
PMID:29376895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5770008/
Abstract

Protothecosis is a rare infection, which has the potential to cause severe disease in patients with underlying immunosuppression. We describe a case of an elderly female with chronic lymphocytic leukemia (CLL), as well as other risk factors, who presented with pustular and erythematous plaques, initially presumed to be leukemia cutis. A biopsy with special stains revealed the lesions to be cutaneous protothecosis, thus presenting a most unusual concurrence of disease entities. The literature to date on this rare infection will be reviewed.

摘要

原藻病是一种罕见的感染性疾病,有潜在可能在潜在免疫抑制患者中引发严重疾病。我们描述了一例老年女性患者,她患有慢性淋巴细胞白血病(CLL)以及其他风险因素,出现了脓疱性和红斑性斑块,最初被认为是皮肤白血病。一次进行了特殊染色的活检显示病变为皮肤原藻病,从而呈现出一种极为罕见的疾病并发情况。本文将对迄今为止关于这种罕见感染的文献进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/75c62cbcdd5b/jof-01-00004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/948c75c35909/jof-01-00004-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/7c089c7383c0/jof-01-00004-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/75c62cbcdd5b/jof-01-00004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/948c75c35909/jof-01-00004-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/7c089c7383c0/jof-01-00004-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/5770008/75c62cbcdd5b/jof-01-00004-g003.jpg

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本文引用的文献

1
Cutaneous protothecosis in a patient with previously undiagnosed HIV infection.一名先前未被诊断出感染艾滋病毒的患者发生皮肤原藻病。
Australas J Dermatol. 2015 Aug;56(3):e71-3. doi: 10.1111/ajd.12153. Epub 2014 Mar 4.
2
Cutaneous protothecosis in a patient with hypogammaglobulinemia.一名低丙种球蛋白血症患者的皮肤原藻病
Med Mycol Case Rep. 2013 Jun 20;2:132-3. doi: 10.1016/j.mmcr.2013.06.002.
3
Human cutaneous protothecosis: report of a case and literature review.人类皮肤原藻病:一例报告及文献综述。
Korean J Pathol. 2013 Dec;47(6):575-8. doi: 10.4132/KoreanJPathol.2013.47.6.575. Epub 2013 Dec 24.
4
Cutaneous protothecosis--case report.皮肤原藻病——病例报告
An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):183-5. doi: 10.1590/abd1806-4841.20132232.
5
Multifocal cutaneous protothecosis in a patient with myelodysplastic syndrome.一名骨髓增生异常综合征患者的多灶性皮肤原藻病
Hippokratia. 2012 Jan;16(1):95.
6
Cutaneous protothecosis: two new cases in China and literature review.皮肤原藻病:中国两例新病例及文献综述
Int J Dermatol. 2012 Mar;51(3):328-31. doi: 10.1111/j.1365-4632.2011.05019.x.
7
A case of cutaneous protothecosis in a polyarteritis nodosa patient and review of cases reported in Japan.一名结节性多动脉炎患者发生皮肤原藻病的病例及日本报道病例的回顾。
Dermatol Online J. 2011 Sep 15;17(9):2.
8
Cutaneous protothecosis in patient with diabetes mellitus and review of published case reports.糖尿病患者皮肤原壁菌病:病例报告分析
Mycopathologia. 2012 Mar;173(2-3):163-71. doi: 10.1007/s11046-011-9480-0. Epub 2011 Oct 2.
9
Cutaneous protothecosis.皮肤原菌病。
Arch Pathol Lab Med. 2011 Jul;135(7):941-4. doi: 10.5858/2010-0017-RSR.1.
10
A case of cutaneous protothecosis successfully treated with local thermal therapy as an adjunct to itraconazole therapy in an immunocompromised host.一例免疫功能低下宿主的皮肤 protothecosis 病例,经局部热疗联合伊曲康唑治疗获得成功。
Med Mycol. 2010 Jun;48(4):643-6. doi: 10.3109/13693780903401690.