从中国红树植物角果木中分离出的两种新的朵拉烷二萜类化合物。
Two New Dolabrane Diterpenes from the Chinese Mangrove Ceriops tagal.
作者信息
Ni Shu-Jun, Li Jun, Li Min-Yi
机构信息
College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, P. R. China.
出版信息
Chem Biodivers. 2018 Mar;15(3):e1700563. doi: 10.1002/cbdv.201700563. Epub 2018 Mar 7.
Two new dolabrane diterpenes, tagalenes J and K (1 and 2), together with eleven known analogues (3 - 13), were isolated from the ethanolic extract of the Chinese mangrove Ceriops tagal. The structures of these compounds were determined by extensive spectroscopic analysis, including 1D-, 2D-NMR and HR-ESI-MS, as well as the comparison with data in the literatures. Cytotoxicities of isolated compounds against MCF-7, SW480, HepG2, HeLa, PANC-1, and A2058 cancer cell lines were also evaluated. Compound 4 exhibited weak cytotoxic activity against SW480, HeLa, and PANC-1 cell lines with IC values of 27.7, 22.2, and 17.6 μm, respectively.
从中国红树植物角果木的乙醇提取物中分离出两种新的多拉烷二萜类化合物，他加林J和K（1和2），以及十一种已知类似物（3 - 13）。这些化合物的结构通过广泛的光谱分析确定，包括一维、二维核磁共振和高分辨电喷雾电离质谱，以及与文献数据的比较。还评估了分离出的化合物对MCF-7、SW480、HepG2、HeLa、PANC-1和A2058癌细胞系的细胞毒性。化合物4对SW480、HeLa和PANC-1细胞系表现出较弱的细胞毒性活性，IC值分别为27.7、22.2和17.6μm。
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