Richardson M Ryan, Arikawa Andrea Y, Churilla James R
Brooks College of Health, University of North Florida , Jacksonville, Florida.
Metab Syndr Relat Disord. 2018 Mar;16(2):104-109. doi: 10.1089/met.2017.0100. Epub 2018 Jan 29.
Some evidence suggests an inverse association between increased fiber intake and C-reactive protein (CRP). However, few studies have examined the associations among CRP, dietary fiber, and leisure-time physical activity (LTPA) in a nationally representative sample of U.S. adults.
Sample (n = 8372) included adults (≥20 years of age) who participated in the 2007-2010 National Health and Nutrition Examination Survey. Tertiles of reported fiber intake were created. The dependent variable was elevated CRP (>3-10 mg/L). Logistic regression models were stratified by LTPA participation and adjusted for age, gender, race, waist circumference (WC), and standing height.
In adults reporting any volume of LTPA participation, increased fiber intake was significantly (P < 0.05 for the upper tertile of fiber intake) associated with lower odds of having an elevated CRP concentration when compared with the lowest tertile. Similar associations were not revealed in analyses limited to adults reporting no LTPA participation. After additional adjustment for WC and standing height, this protective association was no longer statistically significant.
Results suggest that WC and standing height may mediate the beneficial association between increased fiber intake and lower odds of elevated CRP in adults reporting LTPA participation.
一些证据表明膳食纤维摄入量增加与C反应蛋白（CRP）之间存在负相关。然而，很少有研究在美国成年人的全国代表性样本中考察CRP、膳食纤维和休闲时间体力活动（LTPA）之间的关联。
样本（n = 8372）包括参与2007 - 2010年国家健康与营养检查调查的成年人（≥20岁）。根据报告的膳食纤维摄入量划分三分位数。因变量是CRP升高（>3 - 10 mg/L）。逻辑回归模型按LTPA参与情况分层，并对年龄、性别、种族、腰围（WC）和身高进行调整。
在报告有任何LTPA参与量的成年人中，与最低三分位数相比，膳食纤维摄入量增加与CRP浓度升高几率降低显著相关（膳食纤维摄入量最高三分位数时P < 0.05）。在仅限于报告无LTPA参与的成年人的分析中未发现类似关联。在对WC和身高进行额外调整后，这种保护关联不再具有统计学意义。
结果表明，在报告有LTPA参与的成年人中，WC和身高可能介导了膳食纤维摄入量增加与CRP升高几率降低之间的有益关联。
